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Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis

BACKGROUND: Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vit...

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Autores principales: Jeng, Leo, Yamshchikov, Alexandra V, Judd, Suzanne E, Blumberg, Henry M, Martin, Gregory S, Ziegler, Thomas R, Tangpricha, Vin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684740/
https://www.ncbi.nlm.nih.gov/pubmed/19389235
http://dx.doi.org/10.1186/1479-5876-7-28
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author Jeng, Leo
Yamshchikov, Alexandra V
Judd, Suzanne E
Blumberg, Henry M
Martin, Gregory S
Ziegler, Thomas R
Tangpricha, Vin
author_facet Jeng, Leo
Yamshchikov, Alexandra V
Judd, Suzanne E
Blumberg, Henry M
Martin, Gregory S
Ziegler, Thomas R
Tangpricha, Vin
author_sort Jeng, Leo
collection PubMed
description BACKGROUND: Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. METHODS: Plasma concentrations of 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (DBP) and LL-37 in critically ill adult subjects admitted to intensive care units (ICUs) with sepsis and without sepsis were compared to healthy controls. RESULTS: Critically ill subjects had significantly lower plasma 25(OH)D concentrations compared to healthy controls. Mean plasma LL-37 levels were significantly lower in critically ill subjects compared to healthy controls. Vitamin D binding protein levels in plasma were significantly lower in critically ill subjects with sepsis compared to critically ill subjects without sepsis. There was a significant positive association between circulating 25(OH)D and LL-37 levels. CONCLUSION: This study demonstrates an association between critical illness and lower 25(OH)D and DBP levels in critically ill patients as compared to healthy controls. It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Optimal vitamin D status may be important for innate immunity especially in the setting of sepsis. Further invention studies to examine this association are warranted.
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spelling pubmed-26847402009-05-21 Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis Jeng, Leo Yamshchikov, Alexandra V Judd, Suzanne E Blumberg, Henry M Martin, Gregory S Ziegler, Thomas R Tangpricha, Vin J Transl Med Research BACKGROUND: Vitamin D insufficiency is common in hospitalized patients. Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. METHODS: Plasma concentrations of 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (DBP) and LL-37 in critically ill adult subjects admitted to intensive care units (ICUs) with sepsis and without sepsis were compared to healthy controls. RESULTS: Critically ill subjects had significantly lower plasma 25(OH)D concentrations compared to healthy controls. Mean plasma LL-37 levels were significantly lower in critically ill subjects compared to healthy controls. Vitamin D binding protein levels in plasma were significantly lower in critically ill subjects with sepsis compared to critically ill subjects without sepsis. There was a significant positive association between circulating 25(OH)D and LL-37 levels. CONCLUSION: This study demonstrates an association between critical illness and lower 25(OH)D and DBP levels in critically ill patients as compared to healthy controls. It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Optimal vitamin D status may be important for innate immunity especially in the setting of sepsis. Further invention studies to examine this association are warranted. BioMed Central 2009-04-23 /pmc/articles/PMC2684740/ /pubmed/19389235 http://dx.doi.org/10.1186/1479-5876-7-28 Text en Copyright © 2009 Jeng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Jeng, Leo
Yamshchikov, Alexandra V
Judd, Suzanne E
Blumberg, Henry M
Martin, Gregory S
Ziegler, Thomas R
Tangpricha, Vin
Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title_full Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title_fullStr Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title_full_unstemmed Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title_short Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
title_sort alterations in vitamin d status and anti-microbial peptide levels in patients in the intensive care unit with sepsis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684740/
https://www.ncbi.nlm.nih.gov/pubmed/19389235
http://dx.doi.org/10.1186/1479-5876-7-28
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