RANK, RANKL and osteoprotegerin in bone biology and disease

Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This...

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Detalles Bibliográficos
Autores principales: Wright, H. L., McCarthy, H. S., Middleton, J., Marshall, M. J.
Formato: Texto
Lenguaje:English
Publicado: Humana Press Inc 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684955/
https://www.ncbi.nlm.nih.gov/pubmed/19468919
http://dx.doi.org/10.1007/s12178-009-9046-7
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author Wright, H. L.
McCarthy, H. S.
Middleton, J.
Marshall, M. J.
author_facet Wright, H. L.
McCarthy, H. S.
Middleton, J.
Marshall, M. J.
author_sort Wright, H. L.
collection PubMed
description Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This review aims to bring the interested reader up to date with the latest news and views on the mechanisms controlling bone resorption in normal and pathological conditions.
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spelling pubmed-26849552009-05-22 RANK, RANKL and osteoprotegerin in bone biology and disease Wright, H. L. McCarthy, H. S. Middleton, J. Marshall, M. J. Curr Rev Musculoskelet Med Article Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This review aims to bring the interested reader up to date with the latest news and views on the mechanisms controlling bone resorption in normal and pathological conditions. Humana Press Inc 2009-03-10 /pmc/articles/PMC2684955/ /pubmed/19468919 http://dx.doi.org/10.1007/s12178-009-9046-7 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Wright, H. L.
McCarthy, H. S.
Middleton, J.
Marshall, M. J.
RANK, RANKL and osteoprotegerin in bone biology and disease
title RANK, RANKL and osteoprotegerin in bone biology and disease
title_full RANK, RANKL and osteoprotegerin in bone biology and disease
title_fullStr RANK, RANKL and osteoprotegerin in bone biology and disease
title_full_unstemmed RANK, RANKL and osteoprotegerin in bone biology and disease
title_short RANK, RANKL and osteoprotegerin in bone biology and disease
title_sort rank, rankl and osteoprotegerin in bone biology and disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684955/
https://www.ncbi.nlm.nih.gov/pubmed/19468919
http://dx.doi.org/10.1007/s12178-009-9046-7
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AT mccarthyhs rankranklandosteoprotegerininbonebiologyanddisease
AT middletonj rankranklandosteoprotegerininbonebiologyanddisease
AT marshallmj rankranklandosteoprotegerininbonebiologyanddisease

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