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IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
BACKGROUND: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons over time, an...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685016/ https://www.ncbi.nlm.nih.gov/pubmed/19488402 http://dx.doi.org/10.1371/journal.pone.0005768 |