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Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

The promoter of the human KRAS proto-oncogene contains a structurally polymorphic nuclease hypersensitive element (NHE) whose purine strand forms a parallel G-quadruplex structure (called 32R). In a previous work we reported that quadruplex 32R is recognized by three nuclear proteins: PARP-1, Ku70 a...

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Detalles Bibliográficos
Autores principales:	Paramasivam, Manikandan, Membrino, Alexandro, Cogoi, Susanna, Fukuda, Hirokazu, Nakagama, Hitoshi, Xodo, Luigi E.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685089/ https://www.ncbi.nlm.nih.gov/pubmed/19282454 http://dx.doi.org/10.1093/nar/gkp138

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