The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation

Plant homeodomain (PHD) fingers are often present in chromatin-binding proteins and have been shown to bind histone H3 N-terminal tails. Mutations in the autoimmune regulator (AIRE) protein, which harbours two PHD fingers, cause a rare monogenic disease, autoimmune polyendocrinopathy-candidiasis-ect...

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Detalles Bibliográficos
Autores principales: Chignola, Francesca, Gaetani, Massimiliano, Rebane, Ana, Org, Tõnis, Mollica, Luca, Zucchelli, Chiara, Spitaleri, Andrea, Mannella, Valeria, Peterson, Pärt, Musco, Giovanna
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685098/
https://www.ncbi.nlm.nih.gov/pubmed/19293276
http://dx.doi.org/10.1093/nar/gkp166

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