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Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies
Influencing the progression of COPD has long been an elusive goal of drug therapy. Directly or indirectly, this has again been investigated in two of the largest, long-term drug trials in COPD: Towards a Revolution in COPD Health (TORCH) and Understanding Potential Long-Term Impacts on Function with...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685145/ https://www.ncbi.nlm.nih.gov/pubmed/19516917 |
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author | Miravitlles, Marc Anzueto, Antonio |
author_facet | Miravitlles, Marc Anzueto, Antonio |
author_sort | Miravitlles, Marc |
collection | PubMed |
description | Influencing the progression of COPD has long been an elusive goal of drug therapy. Directly or indirectly, this has again been investigated in two of the largest, long-term drug trials in COPD: Towards a Revolution in COPD Health (TORCH) and Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT(®)). Neither trial achieved statistical significance in their respective primary outcomes; however, both make considerable contributions to understanding of how the progression of COPD may be influenced. The objective of this article is to review the data from these different trials with a view to what can be learnt about the management of COPD. The long-term improvements in lung function, health-related quality of life, and possibly survival from the use of long-acting bronchodilators in these trials suggest an influence on progression of the disease. With the more optimistic view of benefits from drug treatment of COPD that these trials provide, a review of prescribing practices is warranted. |
format | Text |
id | pubmed-2685145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26851452009-06-09 Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies Miravitlles, Marc Anzueto, Antonio Int J Chron Obstruct Pulmon Dis Review Influencing the progression of COPD has long been an elusive goal of drug therapy. Directly or indirectly, this has again been investigated in two of the largest, long-term drug trials in COPD: Towards a Revolution in COPD Health (TORCH) and Understanding Potential Long-Term Impacts on Function with Tiotropium (UPLIFT(®)). Neither trial achieved statistical significance in their respective primary outcomes; however, both make considerable contributions to understanding of how the progression of COPD may be influenced. The objective of this article is to review the data from these different trials with a view to what can be learnt about the management of COPD. The long-term improvements in lung function, health-related quality of life, and possibly survival from the use of long-acting bronchodilators in these trials suggest an influence on progression of the disease. With the more optimistic view of benefits from drug treatment of COPD that these trials provide, a review of prescribing practices is warranted. Dove Medical Press 2009 2009-05-07 /pmc/articles/PMC2685145/ /pubmed/19516917 Text en © 2009 Miravitlles and Anzueto, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Miravitlles, Marc Anzueto, Antonio Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title | Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title_full | Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title_fullStr | Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title_full_unstemmed | Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title_short | Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT(®) studies |
title_sort | insights into interventions in managing copd patients: lessons from the torch and uplift(®) studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685145/ https://www.ncbi.nlm.nih.gov/pubmed/19516917 |
work_keys_str_mv | AT miravitllesmarc insightsintointerventionsinmanagingcopdpatientslessonsfromthetorchandupliftstudies AT anzuetoantonio insightsintointerventionsinmanagingcopdpatientslessonsfromthetorchandupliftstudies |