Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene: IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACE

Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1α-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes. In pregnancy, this regulation is uncoupled, and 1,25-(OH)(2)D levels are significantly el...

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Detalles Bibliográficos
Autores principales: Novakovic, Boris, Sibson, Mandy, Ng, Hong Kiat, Manuelpillai, Ursula, Rakyan, Vardhman, Down, Thomas, Beck, Stephan, Fournier, Thierry, Evain-Brion, Danielle, Dimitriadis, Eva, Craig, Jeffrey M., Morley, Ruth, Saffery, Richard
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Transcription, Chromatin, and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685665/
https://www.ncbi.nlm.nih.gov/pubmed/19237542
http://dx.doi.org/10.1074/jbc.M809542200

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