Cargando…

The Structure of an Interdomain Complex That Regulates Talin Activity

Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goult, Benjamin T., Bate, Neil, Anthis, Nicholas J., Wegener, Kate L., Gingras, Alexandre R., Patel, Bipin, Barsukov, Igor L., Campbell, Iain D., Roberts, Gordon C. K., Critchley, David R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685691/ https://www.ncbi.nlm.nih.gov/pubmed/19297334 http://dx.doi.org/10.1074/jbc.M900078200

Ejemplares similares

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
por: Goult, Benjamin T., et al.
Publicado: (2013)

Structural Determinants of Integrin Binding to the Talin Rod
por: Gingras, Alexandre R., et al.
Publicado: (2009)

Control of Periplasmic Interdomain Thiol:Disulfide Exchange in the Transmembrane Oxidoreductase DsbD
por: Mavridou, Despoina A. I., et al.
Publicado: (2009)

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site
por: Goult, Benjamin T., et al.
Publicado: (2010)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding
por: Kostrhon, Sebastian, et al.
Publicado: (2017)

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation
por: Goult, Benjamin T, et al.
Publicado: (2010)

The structure of the C-terminal actin-binding domain of talin
por: Gingras, Alexandre R, et al.
Publicado: (2008)

Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions
por: Vakonakis, Ioannis, et al.
Publicado: (2009)

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
por: Elliott, Paul R., et al.
Publicado: (2010)

Implications for Collagen Binding from the Crystallographic Structure of Fibronectin (6)FnI(1–2)FnII(7)FnI
por: Erat, Michèle C., et al.
Publicado: (2010)

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics
por: Bate, Neil, et al.
Publicado: (2012)

Hydrophobic Core Mutations Associated with Cataract Development in Mice Destabilize Human γD-Crystallin
por: Moreau, Kate L., et al.
Publicado: (2009)

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation
por: Goult, Benjamin T., et al.
Publicado: (2009)

The Structure of the Talin/Integrin Complex at a Lipid Bilayer: An NMR and MD Simulation Study
por: Kalli, Antreas C., et al.
Publicado: (2010)

Crystal Structure of Leishmania major Oligopeptidase B Gives Insight into the Enzymatic Properties of a Trypanosomatid Virulence Factor
por: McLuskey, Karen, et al.
Publicado: (2010)

Evidence for Steric Regulation of Fibrinogen Binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA)
por: Stemberk, Vaclav, et al.
Publicado: (2014)

Lack of an Efficient Endoplasmic Reticulum-localized Recycling System Protects Peroxiredoxin IV from Hyperoxidation
por: Cao, Zhenbo, et al.
Publicado: (2014)

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
por: Tomar, Sakshi, et al.
Publicado: (2015)

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex
por: Zacharchenko, Thomas, et al.
Publicado: (2016)

Protein secondary structure determines the temporal relationship between folding and disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2020)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2017)

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain
por: Salvage, Samantha C., et al.
Publicado: (2019)

Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl Isomerases
por: Jaremko, Łukasz, et al.
Publicado: (2011)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle
por: Cao, Zhenbo, et al.
Publicado: (2011)

Azemiopsin from Azemiops feae Viper Venom, a Novel Polypeptide Ligand of Nicotinic Acetylcholine Receptor
por: Utkin, Yuri N., et al.
Publicado: (2012)

Low Resolution Structure and Dynamics of a Colicin-Receptor Complex Determined by Neutron Scattering
por: Clifton, Luke A., et al.
Publicado: (2012)

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407
por: Anthony, Colin S., et al.
Publicado: (2010)

Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin β-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6
por: Pereira, Jose Henrique, et al.
Publicado: (2016)

N-terminal Domain of Prion Protein Directs Its Oligomeric Association
por: Trevitt, Clare R., et al.
Publicado: (2014)

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer
por: Pedrote, Murilo M., et al.
Publicado: (2018)

Vinculin controls talin engagement with the actomyosin machinery
por: Atherton, Paul, et al.
Publicado: (2015)

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
por: Akerboom, Jasper, et al.
Publicado: (2009)

Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria
por: Jensen, Jaime L., et al.
Publicado: (2020)

Pterocarpan synthase (PTS) structures suggest a common quinone methide–stabilizing function in dirigent proteins and proteins with dirigent-like domains
por: Meng, Qingyan, et al.
Publicado: (2020)

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
por: Valencia-Sánchez, Marco Igor, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r1plo4l60cjhpbt2f8va1eibn3