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Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2
The transcriptional activity of the tumor suppressor p53 requires direct binding between its transactivation domain (TAD, 1-57) and the transcriptional coactivator p300. We systematically assessed the role of TAD phosphorylation on binding of the p300 domains CH3, Taz1, Kix and IBiD. Thr18 phosphory...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685776/ https://www.ncbi.nlm.nih.gov/pubmed/19363523 http://dx.doi.org/10.1038/onc.2009.71 |