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Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway
BACKGROUND: Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE: We investigated the associations of long-term traffic-related exposures with asthma onset assessed retr...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685850/ https://www.ncbi.nlm.nih.gov/pubmed/19478970 http://dx.doi.org/10.1289/ehp.11491 |
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author | Oftedal, Bente Nystad, Wenche Brunekreef, Bert Nafstad, Per |
author_facet | Oftedal, Bente Nystad, Wenche Brunekreef, Bert Nafstad, Per |
author_sort | Oftedal, Bente |
collection | PubMed |
description | BACKGROUND: Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE: We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respiratory symptoms in 9- to 10-year-old children. METHODS: We collected information on respiratory outcomes and potential confounding variables by parental questionnaire in 2,871 children in Oslo. Nitrogen dioxide exposure was assessed by the EPISODE dispersion model and assigned at updated individual addresses during lifetime. Distance to major road was assigned at birth address and address by date of questionnaire. Cox proportional hazard regression and logistic regression were used. RESULTS: We did not find positive associations between any long-term traffic-related exposure and onset of doctor-diagnosed asthma. An interquartile range (IQR) increase of NO(2) exposure before asthma onset was associated with an adjusted risk ratio of 0.82 [95% confidence interval (CI), 0.67–1.02]. Handling early asthma cases (children < 4 years of age) with recovery during follow-up as noncases gave a less negative association. The associations for late asthma onset (≥ 4 years of age) were positive but not statistically significant. For current symptoms, an IQR increase of previous year’s NO(2) exposure was associated with adjusted odds ratios of 1.01 (95% CI, 0.83–1.23) for wheeze, 1.10 (95% CI, 0.79–1.51) for severe wheeze, and 1.01 (95% CI, 0.84–1.21) for dry cough. CONCLUSIONS: We were not able to find positive associations of long-term traffic-related exposures with asthma onset or with current respiratory symptoms in 9- to 10-year-old children in Oslo. |
format | Text |
id | pubmed-2685850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-26858502009-05-27 Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway Oftedal, Bente Nystad, Wenche Brunekreef, Bert Nafstad, Per Environ Health Perspect Research BACKGROUND: Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE: We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respiratory symptoms in 9- to 10-year-old children. METHODS: We collected information on respiratory outcomes and potential confounding variables by parental questionnaire in 2,871 children in Oslo. Nitrogen dioxide exposure was assessed by the EPISODE dispersion model and assigned at updated individual addresses during lifetime. Distance to major road was assigned at birth address and address by date of questionnaire. Cox proportional hazard regression and logistic regression were used. RESULTS: We did not find positive associations between any long-term traffic-related exposure and onset of doctor-diagnosed asthma. An interquartile range (IQR) increase of NO(2) exposure before asthma onset was associated with an adjusted risk ratio of 0.82 [95% confidence interval (CI), 0.67–1.02]. Handling early asthma cases (children < 4 years of age) with recovery during follow-up as noncases gave a less negative association. The associations for late asthma onset (≥ 4 years of age) were positive but not statistically significant. For current symptoms, an IQR increase of previous year’s NO(2) exposure was associated with adjusted odds ratios of 1.01 (95% CI, 0.83–1.23) for wheeze, 1.10 (95% CI, 0.79–1.51) for severe wheeze, and 1.01 (95% CI, 0.84–1.21) for dry cough. CONCLUSIONS: We were not able to find positive associations of long-term traffic-related exposures with asthma onset or with current respiratory symptoms in 9- to 10-year-old children in Oslo. National Institute of Environmental Health Sciences 2009-05 2009-01-30 /pmc/articles/PMC2685850/ /pubmed/19478970 http://dx.doi.org/10.1289/ehp.11491 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Oftedal, Bente Nystad, Wenche Brunekreef, Bert Nafstad, Per Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title | Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title_full | Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title_fullStr | Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title_full_unstemmed | Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title_short | Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway |
title_sort | long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685850/ https://www.ncbi.nlm.nih.gov/pubmed/19478970 http://dx.doi.org/10.1289/ehp.11491 |
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