Cargando…
Chemistry and Biology of DNA Containing 1,N(2)-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal
[Image: see text] The α,β-unsaturated aldehydes (enals) acrolein, crotonaldehyde, and trans-4-hydroxynonenal (4-HNE) are products of endogenous lipid peroxidation, arising as a consequence of oxidative stress. The addition of enals to dG involves Michael addition of the N(2)-amine to give N(2)-(3-ox...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2009
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685875/ https://www.ncbi.nlm.nih.gov/pubmed/19397281 http://dx.doi.org/10.1021/tx9000489 |