Cargando…

Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?

In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected...

Descripción completa

Detalles Bibliográficos
Autores principales: Matowicka-Karna, Joanna, Dymicka-Piekarska, Violetta, Kemona, Halina
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685994/
https://www.ncbi.nlm.nih.gov/pubmed/19478959
http://dx.doi.org/10.1155/2009/374696
_version_ 1782167369131491328
author Matowicka-Karna, Joanna
Dymicka-Piekarska, Violetta
Kemona, Halina
author_facet Matowicka-Karna, Joanna
Dymicka-Piekarska, Violetta
Kemona, Halina
author_sort Matowicka-Karna, Joanna
collection PubMed
description In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected with T. gondii (aged 18–42 years) prior to antiparasitic treatment. In all the patients, we found IgM (index >0.7) and IgG which exceeded 300 IU/ml. The control group (C) consisted of 40 healthy women aged 18–46 years. In the study group (T) and in the control group (C), the levels of IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined. In our study, T. gondii patients had twofold higher levels of IL-5 and IL-6 as compared to healthy subjects, which seems to confirm the presence of an inflammatory state. We found the level of IL-10 to be fivefold higher in the course of toxoplasmosis than in healthy controls. The levels of IL-12 and TNF-α were comparable to those observed in healthy controls. The study has revealed that patients infected with T. gondii show increased production of the humoral response cytokines, whereas the generation of the cell response cytokines remains unchanged.
format Text
id pubmed-2685994
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-26859942009-05-28 Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? Matowicka-Karna, Joanna Dymicka-Piekarska, Violetta Kemona, Halina Clin Dev Immunol Research Article In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected with T. gondii (aged 18–42 years) prior to antiparasitic treatment. In all the patients, we found IgM (index >0.7) and IgG which exceeded 300 IU/ml. The control group (C) consisted of 40 healthy women aged 18–46 years. In the study group (T) and in the control group (C), the levels of IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined. In our study, T. gondii patients had twofold higher levels of IL-5 and IL-6 as compared to healthy subjects, which seems to confirm the presence of an inflammatory state. We found the level of IL-10 to be fivefold higher in the course of toxoplasmosis than in healthy controls. The levels of IL-12 and TNF-α were comparable to those observed in healthy controls. The study has revealed that patients infected with T. gondii show increased production of the humoral response cytokines, whereas the generation of the cell response cytokines remains unchanged. Hindawi Publishing Corporation 2009 2009-05-25 /pmc/articles/PMC2685994/ /pubmed/19478959 http://dx.doi.org/10.1155/2009/374696 Text en Copyright © 2009 Joanna Matowicka-Karna et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matowicka-Karna, Joanna
Dymicka-Piekarska, Violetta
Kemona, Halina
Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title_full Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title_fullStr Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title_full_unstemmed Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title_short Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
title_sort does toxoplasma gondii infection affect the levels of ige and cytokines (il-5, il-6, il-10, il-12, and tnf-alpha)?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685994/
https://www.ncbi.nlm.nih.gov/pubmed/19478959
http://dx.doi.org/10.1155/2009/374696
work_keys_str_mv AT matowickakarnajoanna doestoxoplasmagondiiinfectionaffectthelevelsofigeandcytokinesil5il6il10il12andtnfalpha
AT dymickapiekarskavioletta doestoxoplasmagondiiinfectionaffectthelevelsofigeandcytokinesil5il6il10il12andtnfalpha
AT kemonahalina doestoxoplasmagondiiinfectionaffectthelevelsofigeandcytokinesil5il6il10il12andtnfalpha