Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa

Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility...

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Detalles Bibliográficos
Autores principales: Freeman, Esther E., White, Richard G., Bakker, Roel, Orroth, Kate K., Weiss, Helen A., Buvé, Anne, Hayes, Richard J., Glynn, Judith R.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686080/
https://www.ncbi.nlm.nih.gov/pubmed/19071187
http://dx.doi.org/10.1016/j.vaccine.2008.11.074
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author Freeman, Esther E.
White, Richard G.
Bakker, Roel
Orroth, Kate K.
Weiss, Helen A.
Buvé, Anne
Hayes, Richard J.
Glynn, Judith R.
author_facet Freeman, Esther E.
White, Richard G.
Bakker, Roel
Orroth, Kate K.
Weiss, Helen A.
Buvé, Anne
Hayes, Richard J.
Glynn, Judith R.
author_sort Freeman, Esther E.
collection PubMed
description Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine.
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spelling pubmed-26860802009-05-28 Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa Freeman, Esther E. White, Richard G. Bakker, Roel Orroth, Kate K. Weiss, Helen A. Buvé, Anne Hayes, Richard J. Glynn, Judith R. Vaccine Article Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine. Elsevier Science 2009-02-05 /pmc/articles/PMC2686080/ /pubmed/19071187 http://dx.doi.org/10.1016/j.vaccine.2008.11.074 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Freeman, Esther E.
White, Richard G.
Bakker, Roel
Orroth, Kate K.
Weiss, Helen A.
Buvé, Anne
Hayes, Richard J.
Glynn, Judith R.
Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title_full Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title_fullStr Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title_full_unstemmed Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title_short Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
title_sort population-level effect of potential hsv2 prophylactic vaccines on hiv incidence in sub-saharan africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686080/
https://www.ncbi.nlm.nih.gov/pubmed/19071187
http://dx.doi.org/10.1016/j.vaccine.2008.11.074
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