Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing

Bacterial meningitis and septicaemia is a global health problem often caused by Neisseria meningitidis. The complement system is the most important aspect of host defence against this pathogen, and the critical interaction between the two is influenced by genetic polymorphisms on both the bacterial...

Descripción completa

Detalles Bibliográficos
Autores principales: Kugelberg, Elisabeth, Gollan, Bridget, Tang, Christoph M.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686086/
https://www.ncbi.nlm.nih.gov/pubmed/19388162
http://dx.doi.org/10.1016/j.vaccine.2008.11.059
_version_ 1782167371491835904
author Kugelberg, Elisabeth
Gollan, Bridget
Tang, Christoph M.
author_facet Kugelberg, Elisabeth
Gollan, Bridget
Tang, Christoph M.
author_sort Kugelberg, Elisabeth
collection PubMed
description Bacterial meningitis and septicaemia is a global health problem often caused by Neisseria meningitidis. The complement system is the most important aspect of host defence against this pathogen, and the critical interaction between the two is influenced by genetic polymorphisms on both the bacterial and the host side; variations of the meningococcus may lead to increased survival in human sera, whereas humans with complement deficiencies are more susceptible to meningococcal infections. Here we discuss the mechanisms of meningococcal resistance against complement-mediated killing and the influence of both bacterial and host genetic factors.
format Text
id pubmed-2686086
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-26860862009-05-28 Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing Kugelberg, Elisabeth Gollan, Bridget Tang, Christoph M. Vaccine Article Bacterial meningitis and septicaemia is a global health problem often caused by Neisseria meningitidis. The complement system is the most important aspect of host defence against this pathogen, and the critical interaction between the two is influenced by genetic polymorphisms on both the bacterial and the host side; variations of the meningococcus may lead to increased survival in human sera, whereas humans with complement deficiencies are more susceptible to meningococcal infections. Here we discuss the mechanisms of meningococcal resistance against complement-mediated killing and the influence of both bacterial and host genetic factors. Elsevier Science 2008-12-30 /pmc/articles/PMC2686086/ /pubmed/19388162 http://dx.doi.org/10.1016/j.vaccine.2008.11.059 Text en © 2008 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Kugelberg, Elisabeth
Gollan, Bridget
Tang, Christoph M.
Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title_full Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title_fullStr Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title_full_unstemmed Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title_short Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
title_sort mechanisms in neisseria meningitidis for resistance against complement-mediated killing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686086/
https://www.ncbi.nlm.nih.gov/pubmed/19388162
http://dx.doi.org/10.1016/j.vaccine.2008.11.059
work_keys_str_mv AT kugelbergelisabeth mechanismsinneisseriameningitidisforresistanceagainstcomplementmediatedkilling
AT gollanbridget mechanismsinneisseriameningitidisforresistanceagainstcomplementmediatedkilling
AT tangchristophm mechanismsinneisseriameningitidisforresistanceagainstcomplementmediatedkilling

Ejemplares similares