Cargando…

In Global Health Research, Is It Legitimate To Stop Clinical Trials Early on Account of Their Opportunity Costs?

After the failure of three large clinical trials of vaginal microbicides, a Nature editorial stated that the microbicide field “requires a mechanism to help it make rational choices about the best candidates to move through trials” [1]. In this month's debate, James Lavery and colleagues propos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lavery, James V., Singer, Peter A., Ridzon, Renee, Singh, Jerome A., Slutsky, Arthur S., Anisko, Joseph J., Buchanan, David
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	The PLoS Medicine Debate
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686164/ https://www.ncbi.nlm.nih.gov/pubmed/19513106 http://dx.doi.org/10.1371/journal.pmed.1000071

Ejemplares similares

Which New Approaches to Tackling Neglected Tropical Diseases Show Promise?
por: Spiegel, Jerry M., et al.
Publicado: (2010)

Is It Ethical to Use Enhancement Technologies to Make Us Better than Well?
por: Caplan, Arthur, et al.
Publicado: (2004)

Is the “3 by 5” Initiative the Best Approach to Tackling the HIV Pandemic?
por: Kim, Jim Yong, et al.
Publicado: (2004)

What Should Be Done To Tackle Ghostwriting in the Medical Literature?
por: Gøtzsche, Peter C, et al.
Publicado: (2009)

What Are the Public Health Effects of Direct-to-Consumer Drug Advertising?
por: Almasi, Elizabeth A, et al.
Publicado: (2006)

Can Routine Commercial Cord Blood Banking Be Scientifically and Ethically Justified?
por: Fisk, Nicholas M, et al.
Publicado: (2005)

What Is the Optimal Therapy for Patients with H5N1 Influenza?
por: White, Nicholas J., et al.
Publicado: (2009)

What Are the Roles and Responsibilities of the Media in Disseminating Health Information?
por: Schwitzer, Gary, et al.
Publicado: (2005)

When Should Children with HIV Infection Be Started on Antiretroviral Therapy?
por: Welch, Steven B, et al.
Publicado: (2008)

Should Data from Demographic Surveillance Systems Be Made More Widely Available to Researchers?
por: Chandramohan, Daniel, et al.
Publicado: (2008)

Should Informed Consent for Cancer Treatment Include a Discussion about Hospital Outcome Disparities?
por: Housri, Nadine, et al.
Publicado: (2008)

Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever
por: D'Acremont, Valérie, et al.
Publicado: (2009)

Abandoning Presumptive Antimalarial Treatment for Febrile Children Aged Less Than Five Years—A Case of Running Before We Can Walk?
por: English, Mike, et al.
Publicado: (2009)

Is Private Health Care the Answer to the Health Problems of the World's Poor?
por: Hanson, Kara, et al.
Publicado: (2008)

What Is the Best Approach to Treating Schizophrenia in Developing Countries?
por: Patel, Vikram, et al.
Publicado: (2007)

What Is the Best Approach to Reducing Birth Defects Associated with Isotretinoin?
por: Abroms, Lorien, et al.
Publicado: (2006)

Is It Always Unethical to Use a Placebo in a Clinical Trial?
por: Stang, Andreas, et al.
Publicado: (2005)

What Is the Best Strategy for Reducing Deaths from Heart Disease?
por: Makover, Michael E, et al.
Publicado: (2005)

Should Society Allow Research Ethics Boards to Be Run As For-Profit Enterprises?
por: Emanuel, Ezekiel J, et al.
Publicado: (2006)

Should the Health Community Promote Smokeless Tobacco (Snus) as a Harm Reduction Measure?
por: Gartner, Coral E, et al.
Publicado: (2007)

Which Single Intervention Would Do the Most to Improve the Health of Those Living on Less Than $1 Per Day?
por: Yamey, Gavin
Publicado: (2007)

What Are the Benefits and Risks of Fitting Patients with Radiofrequency Identification Devices
por: Levine, Mark, et al.
Publicado: (2007)

In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?
por: Guyatt, Gordon H, et al.
Publicado: (2008)

Should Health Professionals Screen All Women for Domestic Violence?
por: Taket, Ann, et al.
Publicado: (2004)

Is It Ethical for Patients with Renal Disease to Purchase Kidneys from the World's Poor?
por: Bakdash, Tarif, et al.
Publicado: (2006)

Should an Institution That Has Commercial Rights in a New Drug or Device Be Allowed to Evaluate the Technology?
por: McKinney, Ross, et al.
Publicado: (2005)

Was the “ABC” Approach (Abstinence, Being Faithful, Using Condoms) Responsible for Uganda's Decline in HIV?
por: Murphy, Elaine M, et al.
Publicado: (2006)

Do Electronic Health Records Help or Hinder Medical Education?
por: Peled, Jonathan U., et al.
Publicado: (2009)

Can We Systematically Review Studies That Evaluate Complex Interventions?
por: Shepperd, Sasha, et al.
Publicado: (2009)

Are Drug Companies Living Up to Their Human Rights Responsibilities? The Perspective of the Former United Nations Special Rapporteur (2002-2008)
por: Hunt, Paul, et al.
Publicado: (2010)

Are Drug Companies Living Up to Their Human Rights Responsibilities? The Merck Perspective
por: Ritter, Geralyn S.
Publicado: (2010)

Are Drug Companies Living Up to Their Human Rights Responsibilities? Moving Toward Assessment
por: Gruskin, Sofia, et al.
Publicado: (2010)

Can the Relationship between Doctors and Drug Companies Ever Be a Healthy One?
por: D'Arcy, Emma, et al.
Publicado: (2009)

Are Patents Impeding Medical Care and Innovation?
por: Gold, E. Richard, et al.
Publicado: (2010)

The Case for a Smoker's License
por: Chapman, Simon
Publicado: (2012)

The Case against a Smoker's License
por: Collin, Jeff
Publicado: (2012)

Have Online International Medical Journals Made Local Journals Obsolete?
por: Ofori-Adjei, David, et al.
Publicado: (2006)

A developing country response to Lavery et al. "In global health research, is it legitimate to stop clinical trials early on account of their opportunity costs?"
por: Wassenaar, Douglas R, et al.
Publicado: (2009)

Open Access As Public Policy
por: Gass, Andy
Publicado: (2004)

PLoS Medicine— A Medical Journal for the Internet Age
por: Eisen, Michael B, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_flv67qmit5bfcdcql8slvs5b99