N-acylation of ethanolamine using lipase: a chemoselective catalyst

The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym(®) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supp...

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Detalles Bibliográficos
Autores principales: Kidwai, Mazaahir, Poddar, Roona, Mothsra, Poonam
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314/
https://www.ncbi.nlm.nih.gov/pubmed/19478911
http://dx.doi.org/10.3762/bjoc.5.10
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author Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
author_facet Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
author_sort Kidwai, Mazaahir
collection PubMed
description The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym(®) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.
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spelling pubmed-26863142009-05-28 N-acylation of ethanolamine using lipase: a chemoselective catalyst Kidwai, Mazaahir Poddar, Roona Mothsra, Poonam Beilstein J Org Chem Preliminary Communication The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym(®) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation. Beilstein-Institut 2009-03-25 /pmc/articles/PMC2686314/ /pubmed/19478911 http://dx.doi.org/10.3762/bjoc.5.10 Text en Copyright © 2009, Kidwai et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Preliminary Communication
Kidwai, Mazaahir
Poddar, Roona
Mothsra, Poonam
N-acylation of ethanolamine using lipase: a chemoselective catalyst
title N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_full N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_fullStr N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_full_unstemmed N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_short N-acylation of ethanolamine using lipase: a chemoselective catalyst
title_sort n-acylation of ethanolamine using lipase: a chemoselective catalyst
topic Preliminary Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314/
https://www.ncbi.nlm.nih.gov/pubmed/19478911
http://dx.doi.org/10.3762/bjoc.5.10
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AT poddarroona nacylationofethanolamineusinglipaseachemoselectivecatalyst
AT mothsrapoonam nacylationofethanolamineusinglipaseachemoselectivecatalyst

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