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ER membrane–bending proteins are necessary for de novo nuclear pore formation

Nucleocytoplasmic transport occurs exclusively through nuclear pore complexes (NPCs) embedded in pores formed by inner and outer nuclear membrane fusion. The mechanism for de novo pore and NPC biogenesis remains unclear. Reticulons (RTNs) and Yop1/DP1 are conserved membrane protein families required...

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Detalles Bibliográficos
Autores principales: Dawson, T. Renee, Lazarus, Michelle D., Hetzer, Martin W., Wente, Susan R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686408/
https://www.ncbi.nlm.nih.gov/pubmed/19273614
http://dx.doi.org/10.1083/jcb.200806174