UCbase & miRfunc: a database of ultraconserved sequences and microRNA function

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed...

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Autores principales: Taccioli, Cristian, Fabbri, Enrica, Visone, Rosa, Volinia, Stefano, Calin, George A., Fong, Louise Y., Gambari, Roberto, Bottoni, Arianna, Acunzo, Mario, Hagan, John, Iorio, Marilena V., Piovan, Claudia, Romano, Giulia, Croce, Carlo Maria
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686429/
https://www.ncbi.nlm.nih.gov/pubmed/18945703
http://dx.doi.org/10.1093/nar/gkn702
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author Taccioli, Cristian
Fabbri, Enrica
Visone, Rosa
Volinia, Stefano
Calin, George A.
Fong, Louise Y.
Gambari, Roberto
Bottoni, Arianna
Acunzo, Mario
Hagan, John
Iorio, Marilena V.
Piovan, Claudia
Romano, Giulia
Croce, Carlo Maria
author_facet Taccioli, Cristian
Fabbri, Enrica
Visone, Rosa
Volinia, Stefano
Calin, George A.
Fong, Louise Y.
Gambari, Roberto
Bottoni, Arianna
Acunzo, Mario
Hagan, John
Iorio, Marilena V.
Piovan, Claudia
Romano, Giulia
Croce, Carlo Maria
author_sort Taccioli, Cristian
collection PubMed
description Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.
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spelling pubmed-26864292009-05-26 UCbase & miRfunc: a database of ultraconserved sequences and microRNA function Taccioli, Cristian Fabbri, Enrica Visone, Rosa Volinia, Stefano Calin, George A. Fong, Louise Y. Gambari, Roberto Bottoni, Arianna Acunzo, Mario Hagan, John Iorio, Marilena V. Piovan, Claudia Romano, Giulia Croce, Carlo Maria Nucleic Acids Res Articles Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4. Oxford University Press 2009-01 2008-10-22 /pmc/articles/PMC2686429/ /pubmed/18945703 http://dx.doi.org/10.1093/nar/gkn702 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Taccioli, Cristian
Fabbri, Enrica
Visone, Rosa
Volinia, Stefano
Calin, George A.
Fong, Louise Y.
Gambari, Roberto
Bottoni, Arianna
Acunzo, Mario
Hagan, John
Iorio, Marilena V.
Piovan, Claudia
Romano, Giulia
Croce, Carlo Maria
UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title_full UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title_fullStr UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title_full_unstemmed UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title_short UCbase & miRfunc: a database of ultraconserved sequences and microRNA function
title_sort ucbase & mirfunc: a database of ultraconserved sequences and microrna function
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686429/
https://www.ncbi.nlm.nih.gov/pubmed/18945703
http://dx.doi.org/10.1093/nar/gkn702
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