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Update of KDBI: Kinetic Data of Bio-molecular Interaction database

Knowledge of the kinetics of biomolecular interactions is important for facilitating the study of cellular processes and underlying molecular events, and is essential for quantitative study and simulation of biological systems. Kinetic Data of Bio-molecular Interaction database (KDBI) has been devel...

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Detalles Bibliográficos
Autores principales: Kumar, Pankaj, Han, B. C., Shi, Z., Jia, J., Wang, Y. P., Zhang, Y. T., Liang, L., Liu, Q. F., Ji, Z. L., Chen, Y. Z.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686478/
https://www.ncbi.nlm.nih.gov/pubmed/18971255
http://dx.doi.org/10.1093/nar/gkn839
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author Kumar, Pankaj
Han, B. C.
Shi, Z.
Jia, J.
Wang, Y. P.
Zhang, Y. T.
Liang, L.
Liu, Q. F.
Ji, Z. L.
Chen, Y. Z.
author_facet Kumar, Pankaj
Han, B. C.
Shi, Z.
Jia, J.
Wang, Y. P.
Zhang, Y. T.
Liang, L.
Liu, Q. F.
Ji, Z. L.
Chen, Y. Z.
author_sort Kumar, Pankaj
collection PubMed
description Knowledge of the kinetics of biomolecular interactions is important for facilitating the study of cellular processes and underlying molecular events, and is essential for quantitative study and simulation of biological systems. Kinetic Data of Bio-molecular Interaction database (KDBI) has been developed to provide information about experimentally determined kinetic data of protein–protein, protein–nucleic acid, protein–ligand, nucleic acid–ligand binding or reaction events described in the literature. To accommodate increasing demand for studying and simulating biological systems, numerous improvements and updates have been made to KDBI, including new ways to access data by pathway and molecule names, data file in System Biology Markup Language format, more efficient search engine, access to published parameter sets of simulation models of 63 pathways, and 2.3-fold increase of data (19 263 entries of 10 532 distinctive biomolecular binding and 11 954 interaction events, involving 2635 proteins/protein complexes, 847 nucleic acids, 1603 small molecules and 45 multi-step processes). KDBI is publically available at http://bidd.nus.edu.sg/group/kdbi/kdbi.asp.
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spelling pubmed-26864782009-05-26 Update of KDBI: Kinetic Data of Bio-molecular Interaction database Kumar, Pankaj Han, B. C. Shi, Z. Jia, J. Wang, Y. P. Zhang, Y. T. Liang, L. Liu, Q. F. Ji, Z. L. Chen, Y. Z. Nucleic Acids Res Articles Knowledge of the kinetics of biomolecular interactions is important for facilitating the study of cellular processes and underlying molecular events, and is essential for quantitative study and simulation of biological systems. Kinetic Data of Bio-molecular Interaction database (KDBI) has been developed to provide information about experimentally determined kinetic data of protein–protein, protein–nucleic acid, protein–ligand, nucleic acid–ligand binding or reaction events described in the literature. To accommodate increasing demand for studying and simulating biological systems, numerous improvements and updates have been made to KDBI, including new ways to access data by pathway and molecule names, data file in System Biology Markup Language format, more efficient search engine, access to published parameter sets of simulation models of 63 pathways, and 2.3-fold increase of data (19 263 entries of 10 532 distinctive biomolecular binding and 11 954 interaction events, involving 2635 proteins/protein complexes, 847 nucleic acids, 1603 small molecules and 45 multi-step processes). KDBI is publically available at http://bidd.nus.edu.sg/group/kdbi/kdbi.asp. Oxford University Press 2009-01 2008-10-29 /pmc/articles/PMC2686478/ /pubmed/18971255 http://dx.doi.org/10.1093/nar/gkn839 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Kumar, Pankaj
Han, B. C.
Shi, Z.
Jia, J.
Wang, Y. P.
Zhang, Y. T.
Liang, L.
Liu, Q. F.
Ji, Z. L.
Chen, Y. Z.
Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title_full Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title_fullStr Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title_full_unstemmed Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title_short Update of KDBI: Kinetic Data of Bio-molecular Interaction database
title_sort update of kdbi: kinetic data of bio-molecular interaction database
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686478/
https://www.ncbi.nlm.nih.gov/pubmed/18971255
http://dx.doi.org/10.1093/nar/gkn839
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