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Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight

A male sheep linkage map comprising 191 microsatellites was generated from a single family of 510 Awassi-Merino backcross progeny. Except for ovine chromosomes 1, 2, 10 and 17, all other chromosomes yielded a LOD score difference greater than 3.0 between the best and second-best map order. The map i...

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Autores principales: Raadsma, Herman W, Thomson, Peter C, Zenger, Kyall R, Cavanagh, Colin, Lam, Mary K, Jonas, Elisabeth, Jones, Marilyn, Attard, Gina, Palmer, David, Nicholas, Frank W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686678/
https://www.ncbi.nlm.nih.gov/pubmed/19389264
http://dx.doi.org/10.1186/1297-9686-41-34
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author Raadsma, Herman W
Thomson, Peter C
Zenger, Kyall R
Cavanagh, Colin
Lam, Mary K
Jonas, Elisabeth
Jones, Marilyn
Attard, Gina
Palmer, David
Nicholas, Frank W
author_facet Raadsma, Herman W
Thomson, Peter C
Zenger, Kyall R
Cavanagh, Colin
Lam, Mary K
Jonas, Elisabeth
Jones, Marilyn
Attard, Gina
Palmer, David
Nicholas, Frank W
author_sort Raadsma, Herman W
collection PubMed
description A male sheep linkage map comprising 191 microsatellites was generated from a single family of 510 Awassi-Merino backcross progeny. Except for ovine chromosomes 1, 2, 10 and 17, all other chromosomes yielded a LOD score difference greater than 3.0 between the best and second-best map order. The map is on average 11% longer than the Sheep Linkage Map v4.7 male-specific map. This map was employed in quantitative trait loci (QTL) analyses on body-weight and growth-rate traits between birth and 98 weeks of age. A custom maximum likelihood program was developed to map QTL in half-sib families for non-inbred strains (QTL-MLE) and is freely available on request. The new analysis package offers the advantage of enabling QTL × fixed effect interactions to be included in the model. Fifty-four putative QTL were identified on nine chromosomes. Significant QTL with sex-specific effects (i.e. QTL × sex interaction) in the range of 0.4 to 0.7 SD were found on ovine chromosomes 1, 3, 6, 11, 21, 23, 24 and 26.
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spelling pubmed-26866782009-05-27 Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight Raadsma, Herman W Thomson, Peter C Zenger, Kyall R Cavanagh, Colin Lam, Mary K Jonas, Elisabeth Jones, Marilyn Attard, Gina Palmer, David Nicholas, Frank W Genet Sel Evol Research A male sheep linkage map comprising 191 microsatellites was generated from a single family of 510 Awassi-Merino backcross progeny. Except for ovine chromosomes 1, 2, 10 and 17, all other chromosomes yielded a LOD score difference greater than 3.0 between the best and second-best map order. The map is on average 11% longer than the Sheep Linkage Map v4.7 male-specific map. This map was employed in quantitative trait loci (QTL) analyses on body-weight and growth-rate traits between birth and 98 weeks of age. A custom maximum likelihood program was developed to map QTL in half-sib families for non-inbred strains (QTL-MLE) and is freely available on request. The new analysis package offers the advantage of enabling QTL × fixed effect interactions to be included in the model. Fifty-four putative QTL were identified on nine chromosomes. Significant QTL with sex-specific effects (i.e. QTL × sex interaction) in the range of 0.4 to 0.7 SD were found on ovine chromosomes 1, 3, 6, 11, 21, 23, 24 and 26. BioMed Central 2009-04-24 /pmc/articles/PMC2686678/ /pubmed/19389264 http://dx.doi.org/10.1186/1297-9686-41-34 Text en Copyright © 2009 Raadsma et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Raadsma, Herman W
Thomson, Peter C
Zenger, Kyall R
Cavanagh, Colin
Lam, Mary K
Jonas, Elisabeth
Jones, Marilyn
Attard, Gina
Palmer, David
Nicholas, Frank W
Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title_full Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title_fullStr Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title_full_unstemmed Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title_short Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
title_sort mapping quantitative trait loci (qtl) in sheep. i. a new male framework linkage map and qtl for growth rate and body weight
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686678/
https://www.ncbi.nlm.nih.gov/pubmed/19389264
http://dx.doi.org/10.1186/1297-9686-41-34
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