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Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca(2+ )concentration, phosphorylation of ERK and activation of ternary complex factor
BACKGROUND: The serine protease thrombin catalyzes fibrin clot formation by converting fibrinogen into fibrin. Additionally, thrombin stimulation leads to an activation of stimulus-responsive transcription factors in different cell types, indicating that the gene expression pattern is changed in thr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686679/ https://www.ncbi.nlm.nih.gov/pubmed/19432968 http://dx.doi.org/10.1186/1471-2199-10-40 |