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Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo
Connective tissue growth factor (CCN2) is a major pro-fibrotic factor that frequently acts downstream of transforming growth factor beta (TGF-β)-mediated fibrogenic pathways. Much of our knowledge of CCN2 in fibrosis has come from studies in which its production or activity have been experimentally...
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Formato: | Texto |
Lenguaje: | English |
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Springer Netherlands
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686750/ https://www.ncbi.nlm.nih.gov/pubmed/19294531 http://dx.doi.org/10.1007/s12079-009-0043-9 |
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author | Brigstock, David R. |
author_facet | Brigstock, David R. |
author_sort | Brigstock, David R. |
collection | PubMed |
description | Connective tissue growth factor (CCN2) is a major pro-fibrotic factor that frequently acts downstream of transforming growth factor beta (TGF-β)-mediated fibrogenic pathways. Much of our knowledge of CCN2 in fibrosis has come from studies in which its production or activity have been experimentally attenuated. These studies, performed both in vitro and in animal models, have demonstrated the utility of pharmacological inhibitors (e.g. tumor necrosis factor alpha (TNF-α), prostaglandins, peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists, statins, kinase inhibitors), neutralizing antibodies, antisense oligonucleotides, or small interfering RNA (siRNA) to probe the role of CCN2 in fibrogenic pathways. These investigations have allowed the mechanisms regulating CCN2 production to be more clearly defined, have shown that CCN2 is a rational anti-fibrotic target, and have established a framework for developing effective modalities of therapeutic intervention in vivo. |
format | Text |
id | pubmed-2686750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-26867502009-06-08 Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo Brigstock, David R. J Cell Commun Signal Research Article Connective tissue growth factor (CCN2) is a major pro-fibrotic factor that frequently acts downstream of transforming growth factor beta (TGF-β)-mediated fibrogenic pathways. Much of our knowledge of CCN2 in fibrosis has come from studies in which its production or activity have been experimentally attenuated. These studies, performed both in vitro and in animal models, have demonstrated the utility of pharmacological inhibitors (e.g. tumor necrosis factor alpha (TNF-α), prostaglandins, peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists, statins, kinase inhibitors), neutralizing antibodies, antisense oligonucleotides, or small interfering RNA (siRNA) to probe the role of CCN2 in fibrogenic pathways. These investigations have allowed the mechanisms regulating CCN2 production to be more clearly defined, have shown that CCN2 is a rational anti-fibrotic target, and have established a framework for developing effective modalities of therapeutic intervention in vivo. Springer Netherlands 2009-03-18 2009-03 /pmc/articles/PMC2686750/ /pubmed/19294531 http://dx.doi.org/10.1007/s12079-009-0043-9 Text en © The Author(s) 2009 |
spellingShingle | Research Article Brigstock, David R. Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title | Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title_full | Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title_fullStr | Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title_full_unstemmed | Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title_short | Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo |
title_sort | strategies for blocking the fibrogenic actions of connective tissue growth factor (ccn2): from pharmacological inhibition in vitro to targeted sirna therapy in vivo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686750/ https://www.ncbi.nlm.nih.gov/pubmed/19294531 http://dx.doi.org/10.1007/s12079-009-0043-9 |
work_keys_str_mv | AT brigstockdavidr strategiesforblockingthefibrogenicactionsofconnectivetissuegrowthfactorccn2frompharmacologicalinhibitioninvitrototargetedsirnatherapyinvivo |