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Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo
Connective tissue growth factor (CCN2) is a major pro-fibrotic factor that frequently acts downstream of transforming growth factor beta (TGF-β)-mediated fibrogenic pathways. Much of our knowledge of CCN2 in fibrosis has come from studies in which its production or activity have been experimentally...
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| Formato: | Texto |
| Lenguaje: | English |
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Springer Netherlands
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686750/ https://www.ncbi.nlm.nih.gov/pubmed/19294531 http://dx.doi.org/10.1007/s12079-009-0043-9 |