Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element

Wnt proteins elevate expression of the CCN family. For example, Wnt10b induces the fibrogenic pro-adhesive molecule connective tissue growth factor (CTGF, CCN2) in NIH 3T3 fibroblasts. Wnt10b activates the CCN2 minimal promoter. In this report, we map the Wnt10b response element in the CCN2 minimal...

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Detalles Bibliográficos
Autores principales: Chen, Shaoqiong, Leask, Andrew
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686755/
https://www.ncbi.nlm.nih.gov/pubmed/19353303
http://dx.doi.org/10.1007/s12079-009-0049-3
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author Chen, Shaoqiong
Leask, Andrew
author_facet Chen, Shaoqiong
Leask, Andrew
author_sort Chen, Shaoqiong
collection PubMed
description Wnt proteins elevate expression of the CCN family. For example, Wnt10b induces the fibrogenic pro-adhesive molecule connective tissue growth factor (CTGF, CCN2) in NIH 3T3 fibroblasts. Wnt10b activates the CCN2 minimal promoter. In this report, we map the Wnt10b response element in the CCN2 minimal promoter to the previously identified Smad response element. These results suggest that Wnts may cross-talk with the Smad signaling pathway to induce fibrotic responses in fibroblasts.
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spelling pubmed-26867552009-06-08 Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element Chen, Shaoqiong Leask, Andrew J Cell Commun Signal Research Article Wnt proteins elevate expression of the CCN family. For example, Wnt10b induces the fibrogenic pro-adhesive molecule connective tissue growth factor (CTGF, CCN2) in NIH 3T3 fibroblasts. Wnt10b activates the CCN2 minimal promoter. In this report, we map the Wnt10b response element in the CCN2 minimal promoter to the previously identified Smad response element. These results suggest that Wnts may cross-talk with the Smad signaling pathway to induce fibrotic responses in fibroblasts. Springer Netherlands 2009-04-08 2009-03 /pmc/articles/PMC2686755/ /pubmed/19353303 http://dx.doi.org/10.1007/s12079-009-0049-3 Text en © The Author(s) 2009
spellingShingle Research Article
Chen, Shaoqiong
Leask, Andrew
Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title_full Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title_fullStr Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title_full_unstemmed Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title_short Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element
title_sort wnt 10b activates the ccn2 promoter in nih 3t3 fibroblasts through the smad response element
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686755/
https://www.ncbi.nlm.nih.gov/pubmed/19353303
http://dx.doi.org/10.1007/s12079-009-0049-3
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AT leaskandrew wnt10bactivatestheccn2promoterinnih3t3fibroblaststhroughthesmadresponseelement

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