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Cognitive Impairment in Juvenile Myoclonic Epilepsy
BACKGROUND AND PURPOSE: Cognitive impairments are frequent consequences of epilepsy, with intellectual ability reportedly being lower in patients with idiopathic generalized epilepsies than in the general population. However, neuropsychological investigations have been rarely performed in patients w...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Neurological Association
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686860/ https://www.ncbi.nlm.nih.gov/pubmed/19513297 http://dx.doi.org/10.3988/jcn.2007.3.2.86 |
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author | Kim, Sun-Young Hwang, Yang-Ha Lee, Ho-Won Suh, Chung-Kyu Kwon, Soon-Hak Park, Sung-Pa |
author_facet | Kim, Sun-Young Hwang, Yang-Ha Lee, Ho-Won Suh, Chung-Kyu Kwon, Soon-Hak Park, Sung-Pa |
author_sort | Kim, Sun-Young |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Cognitive impairments are frequent consequences of epilepsy, with intellectual ability reportedly being lower in patients with idiopathic generalized epilepsies than in the general population. However, neuropsychological investigations have been rarely performed in patients with juvenile myoclonic epilepsy (JME). We aimed to quantify the cognitive function in JME patients using various neuropsychological tests. METHODS: We compared cognitive function in 27 JME patients with that in 27 healthy volunteers using tests examining cognitive performance, such as the verbal and visual memory, frontal function, attention, IQ score, and mood. In the JME group, we examined risk factors for cognitive function such as age, sex, family history, education level, age at seizure onset, seizure frequency, EEG abnormality, disease duration, and previous intake of antiepileptic drugs. RESULTS: Verbal learning was significantly lower in JME patients than in controls, and attention and verbal fluency were impaired in JME patients compared with controls. However, general intellectual ability and mood did not differ between the groups. Early onset of seizure and long duration of disease were closely related to impaired cognitive function. CONCLUSIONS: JME patients may exhibit impaired cognitive function, in terms of memory and execution, despite having normal intelligence and mood. |
format | Text |
id | pubmed-2686860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-26868602009-06-09 Cognitive Impairment in Juvenile Myoclonic Epilepsy Kim, Sun-Young Hwang, Yang-Ha Lee, Ho-Won Suh, Chung-Kyu Kwon, Soon-Hak Park, Sung-Pa J Clin Neurol Original Article BACKGROUND AND PURPOSE: Cognitive impairments are frequent consequences of epilepsy, with intellectual ability reportedly being lower in patients with idiopathic generalized epilepsies than in the general population. However, neuropsychological investigations have been rarely performed in patients with juvenile myoclonic epilepsy (JME). We aimed to quantify the cognitive function in JME patients using various neuropsychological tests. METHODS: We compared cognitive function in 27 JME patients with that in 27 healthy volunteers using tests examining cognitive performance, such as the verbal and visual memory, frontal function, attention, IQ score, and mood. In the JME group, we examined risk factors for cognitive function such as age, sex, family history, education level, age at seizure onset, seizure frequency, EEG abnormality, disease duration, and previous intake of antiepileptic drugs. RESULTS: Verbal learning was significantly lower in JME patients than in controls, and attention and verbal fluency were impaired in JME patients compared with controls. However, general intellectual ability and mood did not differ between the groups. Early onset of seizure and long duration of disease were closely related to impaired cognitive function. CONCLUSIONS: JME patients may exhibit impaired cognitive function, in terms of memory and execution, despite having normal intelligence and mood. Korean Neurological Association 2007-06 2007-06-20 /pmc/articles/PMC2686860/ /pubmed/19513297 http://dx.doi.org/10.3988/jcn.2007.3.2.86 Text en Copyright © 2007 Korean Neurological Association |
spellingShingle | Original Article Kim, Sun-Young Hwang, Yang-Ha Lee, Ho-Won Suh, Chung-Kyu Kwon, Soon-Hak Park, Sung-Pa Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title | Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title_full | Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title_fullStr | Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title_full_unstemmed | Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title_short | Cognitive Impairment in Juvenile Myoclonic Epilepsy |
title_sort | cognitive impairment in juvenile myoclonic epilepsy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686860/ https://www.ncbi.nlm.nih.gov/pubmed/19513297 http://dx.doi.org/10.3988/jcn.2007.3.2.86 |
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