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Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction

BACKGROUND AND PURPOSE: Progression of motor deficits in the acute period is frequently observed in patients with subcortical striatocapsular infarctions. Therefore, we sought to determine the factors associated with early motor progression in patients with infarcts confined to the striatocapsular r...

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Autores principales: Moon, Heui-Soo, Kim, Yong-Bum, Suh, Bum-Chun, Won, Yu Sam, Park, Kwang-Yeol, Chung, Pil-Wook
Formato: Texto
Lenguaje:English
Publicado: Korean Neurological Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686879/
https://www.ncbi.nlm.nih.gov/pubmed/19513313
http://dx.doi.org/10.3988/jcn.2008.4.3.111
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author Moon, Heui-Soo
Kim, Yong-Bum
Suh, Bum-Chun
Won, Yu Sam
Park, Kwang-Yeol
Chung, Pil-Wook
author_facet Moon, Heui-Soo
Kim, Yong-Bum
Suh, Bum-Chun
Won, Yu Sam
Park, Kwang-Yeol
Chung, Pil-Wook
author_sort Moon, Heui-Soo
collection PubMed
description BACKGROUND AND PURPOSE: Progression of motor deficits in the acute period is frequently observed in patients with subcortical striatocapsular infarctions. Therefore, we sought to determine the factors associated with early motor progression in patients with infarcts confined to the striatocapsular region. METHODS: We studied 80 consecutive patients with striatocapsular-region infarction, as defined by clinical and MRI criteria, within 24 hours after stroke onset. Motor progression was defined as an increase of >2 points in the motor items of the National Institutes of Health Stroke Scale (NIHSS) within 7 days of stroke onset. The study population was divided into patients with and without motor progression, and risk factors, clinical features, and brain MRI/magnetic resonance angiograpy (MRA) findings were compared between these groups. RESULTS: Motor progression was observed in 40% of the 80 patients. The independent variables associated with motor progression were a history of hypertension (OR=7.8, 95% CI=1.5-39.8, p=0.013) and an initial infarct extent of ≥15 mm (OR=9.2, 95% CI=1.8-45.7, p=0.006). However, there were no differences in the initial NIHSS score, other stroke risk factors, vascular stenosis pattern, or cardioembolic source. CONCLUSIONS: Early motor progression in patients with striatocapsular-region infarction is associated with the initial extent of the lesion. However, the stroke mechanism and vascular stenosis did not differ between the motor progression and stable groups.
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spelling pubmed-26868792009-06-09 Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction Moon, Heui-Soo Kim, Yong-Bum Suh, Bum-Chun Won, Yu Sam Park, Kwang-Yeol Chung, Pil-Wook J Clin Neurol Original Article BACKGROUND AND PURPOSE: Progression of motor deficits in the acute period is frequently observed in patients with subcortical striatocapsular infarctions. Therefore, we sought to determine the factors associated with early motor progression in patients with infarcts confined to the striatocapsular region. METHODS: We studied 80 consecutive patients with striatocapsular-region infarction, as defined by clinical and MRI criteria, within 24 hours after stroke onset. Motor progression was defined as an increase of >2 points in the motor items of the National Institutes of Health Stroke Scale (NIHSS) within 7 days of stroke onset. The study population was divided into patients with and without motor progression, and risk factors, clinical features, and brain MRI/magnetic resonance angiograpy (MRA) findings were compared between these groups. RESULTS: Motor progression was observed in 40% of the 80 patients. The independent variables associated with motor progression were a history of hypertension (OR=7.8, 95% CI=1.5-39.8, p=0.013) and an initial infarct extent of ≥15 mm (OR=9.2, 95% CI=1.8-45.7, p=0.006). However, there were no differences in the initial NIHSS score, other stroke risk factors, vascular stenosis pattern, or cardioembolic source. CONCLUSIONS: Early motor progression in patients with striatocapsular-region infarction is associated with the initial extent of the lesion. However, the stroke mechanism and vascular stenosis did not differ between the motor progression and stable groups. Korean Neurological Association 2008-09 2008-09-30 /pmc/articles/PMC2686879/ /pubmed/19513313 http://dx.doi.org/10.3988/jcn.2008.4.3.111 Text en Copyright © 2008 Korean Neurological Association
spellingShingle Original Article
Moon, Heui-Soo
Kim, Yong-Bum
Suh, Bum-Chun
Won, Yu Sam
Park, Kwang-Yeol
Chung, Pil-Wook
Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title_full Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title_fullStr Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title_full_unstemmed Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title_short Association of Initial Infarct Extent and Progressive Motor Deficits in Striatocapsular Infarction
title_sort association of initial infarct extent and progressive motor deficits in striatocapsular infarction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686879/
https://www.ncbi.nlm.nih.gov/pubmed/19513313
http://dx.doi.org/10.3988/jcn.2008.4.3.111
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