Oral Administration of Memantine Prolongs Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

BACKGROUND AND PURPOSE: N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and oxidative stress have been implicated in the etiology of amyotrophic lateral sclerosis (ALS). Memantine is a low-affinity, noncompetitive NMDA receptor antagonist that may protect against motor neuron degeneration. METHOD...

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Detalles Bibliográficos
Autores principales: Joo, In-Soo, Hwang, Dong-Hoon, Seok, Jung-Im, Shin, Sang-Kun, Kim, Seung-Up
Formato: Texto
Lenguaje:English
Publicado: Korean Neurological Association 2007
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686946/
https://www.ncbi.nlm.nih.gov/pubmed/19513129
http://dx.doi.org/10.3988/jcn.2007.3.4.181

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