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Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors

BACKGROUND: D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor. MATERIALS/METHODS: Subjects comprised 77 patients who had undergone onc...

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Autores principales: Morii, Takeshi, Mochizuki, Kazuo, Kotera, Masazumi, Imakiire, Naoaki, Moriwaki, Takahiro, Satomi, Kazuhiko
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687121/
https://www.ncbi.nlm.nih.gov/pubmed/19478888
http://dx.doi.org/10.2174/1874325000802010130
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author Morii, Takeshi
Mochizuki, Kazuo
Kotera, Masazumi
Imakiire, Naoaki
Moriwaki, Takahiro
Satomi, Kazuhiko
author_facet Morii, Takeshi
Mochizuki, Kazuo
Kotera, Masazumi
Imakiire, Naoaki
Moriwaki, Takahiro
Satomi, Kazuhiko
author_sort Morii, Takeshi
collection PubMed
description BACKGROUND: D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor. MATERIALS/METHODS: Subjects comprised 77 patients who had undergone oncological resection of musculoskeletal tumor. DD levels were assessed preoperatively and on postoperative days 1 and 7. Multidetector-row computed tomography (MD-CT) was performed to detect DVT/PE for cases with DD level >10.0 µg/ml. RESULTS: Mean preoperative DD level was 0.84 µg/ml. Significant elevation of postoperative DD levels was confirmed. DD levels were significantly changed by various clinical conditions, such as malignancy, age and prosthetic reconstruction. In 4 of 5 cases with postoperative DD levels >10.0 µg/ml, DVT/PE was detected. CONCLUSION: Activation of the coagulation system by surgery and heterogeneity of DD levels under various clinical conditions in musculoskeletal tumor patients were suggested.
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spelling pubmed-26871212009-05-28 Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors Morii, Takeshi Mochizuki, Kazuo Kotera, Masazumi Imakiire, Naoaki Moriwaki, Takahiro Satomi, Kazuhiko Open Orthop J Article BACKGROUND: D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor. MATERIALS/METHODS: Subjects comprised 77 patients who had undergone oncological resection of musculoskeletal tumor. DD levels were assessed preoperatively and on postoperative days 1 and 7. Multidetector-row computed tomography (MD-CT) was performed to detect DVT/PE for cases with DD level >10.0 µg/ml. RESULTS: Mean preoperative DD level was 0.84 µg/ml. Significant elevation of postoperative DD levels was confirmed. DD levels were significantly changed by various clinical conditions, such as malignancy, age and prosthetic reconstruction. In 4 of 5 cases with postoperative DD levels >10.0 µg/ml, DVT/PE was detected. CONCLUSION: Activation of the coagulation system by surgery and heterogeneity of DD levels under various clinical conditions in musculoskeletal tumor patients were suggested. Bentham Open 2008-08-26 /pmc/articles/PMC2687121/ /pubmed/19478888 http://dx.doi.org/10.2174/1874325000802010130 Text en © Morii et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Morii, Takeshi
Mochizuki, Kazuo
Kotera, Masazumi
Imakiire, Naoaki
Moriwaki, Takahiro
Satomi, Kazuhiko
Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title_full Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title_fullStr Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title_full_unstemmed Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title_short Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
title_sort perioperative d-dimer levels in patients with musculoskeletal tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687121/
https://www.ncbi.nlm.nih.gov/pubmed/19478888
http://dx.doi.org/10.2174/1874325000802010130
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