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Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life

INTRODUCTION: Immaturity of motility, intestinal epithelial barrier function and absorptive capacity may play a role in the pathophysiology of intestinal diseases in preterms. We determined the gastric electrical activity and emptying, and intestinal permeability, in preterm newborns to verify if a...

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Autores principales: Riezzo, Giuseppe, Indrio, Flavia, Raimondi, Francesco, Montagna, Osvaldo, Salvia, Gennaro, Massimo, Bisceglia, Polimeno, Lorenzo, Cavallo, Luciano, Francavilla, Ruggiero
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687546/
https://www.ncbi.nlm.nih.gov/pubmed/19490663
http://dx.doi.org/10.1186/1824-7288-35-6
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author Riezzo, Giuseppe
Indrio, Flavia
Raimondi, Francesco
Montagna, Osvaldo
Salvia, Gennaro
Massimo, Bisceglia
Polimeno, Lorenzo
Cavallo, Luciano
Francavilla, Ruggiero
author_facet Riezzo, Giuseppe
Indrio, Flavia
Raimondi, Francesco
Montagna, Osvaldo
Salvia, Gennaro
Massimo, Bisceglia
Polimeno, Lorenzo
Cavallo, Luciano
Francavilla, Ruggiero
author_sort Riezzo, Giuseppe
collection PubMed
description INTRODUCTION: Immaturity of motility, intestinal epithelial barrier function and absorptive capacity may play a role in the pathophysiology of intestinal diseases in preterms. We determined the gastric electrical activity and emptying, and intestinal permeability, in preterm newborns to verify if a maturation pattern exists in preterm newborns during the first month of life. PATIENTS AND METHODS: Eighteen preterm newborns (median 34 wks, range 2 wks) completed the study. They underwent the recording of gastric electrical activity by means of cutaneous electrogastrography, the ultrasound examination of gastric emptying, and the lactulose-to-mannitol ratio from permeability-absorption test on days 3, 7, 15, and 30 after birth. RESULTS: Gastric electrical activity and emptying showed only slight changes between day 3 and day 7. On the contrary, an evident maturation in permeability, expressed as L/Mratio, was evident over time (Friedman Repeated Measures Analysis, p = 0.004). CONCLUSION: In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life.
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spelling pubmed-26875462009-05-30 Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life Riezzo, Giuseppe Indrio, Flavia Raimondi, Francesco Montagna, Osvaldo Salvia, Gennaro Massimo, Bisceglia Polimeno, Lorenzo Cavallo, Luciano Francavilla, Ruggiero Ital J Pediatr Research INTRODUCTION: Immaturity of motility, intestinal epithelial barrier function and absorptive capacity may play a role in the pathophysiology of intestinal diseases in preterms. We determined the gastric electrical activity and emptying, and intestinal permeability, in preterm newborns to verify if a maturation pattern exists in preterm newborns during the first month of life. PATIENTS AND METHODS: Eighteen preterm newborns (median 34 wks, range 2 wks) completed the study. They underwent the recording of gastric electrical activity by means of cutaneous electrogastrography, the ultrasound examination of gastric emptying, and the lactulose-to-mannitol ratio from permeability-absorption test on days 3, 7, 15, and 30 after birth. RESULTS: Gastric electrical activity and emptying showed only slight changes between day 3 and day 7. On the contrary, an evident maturation in permeability, expressed as L/Mratio, was evident over time (Friedman Repeated Measures Analysis, p = 0.004). CONCLUSION: In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life. BioMed Central 2009-03-15 /pmc/articles/PMC2687546/ /pubmed/19490663 http://dx.doi.org/10.1186/1824-7288-35-6 Text en Copyright © 2009 Riezzo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Riezzo, Giuseppe
Indrio, Flavia
Raimondi, Francesco
Montagna, Osvaldo
Salvia, Gennaro
Massimo, Bisceglia
Polimeno, Lorenzo
Cavallo, Luciano
Francavilla, Ruggiero
Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title_full Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title_fullStr Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title_full_unstemmed Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title_short Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
title_sort maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687546/
https://www.ncbi.nlm.nih.gov/pubmed/19490663
http://dx.doi.org/10.1186/1824-7288-35-6
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