Cargando…
Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey
Primary gastrointestinal lymphoma is a common presentation of non-Hodgkin's lymphoma. The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathol...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687578/ https://www.ncbi.nlm.nih.gov/pubmed/16502482 http://dx.doi.org/10.3349/ymj.2006.47.1.22 |
_version_ | 1782167545665552384 |
---|---|
author | Eser, Bulent Kaplan, Bunyamin Unal, Ali Canoz, Ozlem Altuntas, Fevzi Sari, H. Ismail. Er, Ozlem Ozkan, Metin Kucuk, Can Arar, Makbule Gursoy, Sebnem Cetin, Mustafa |
author_facet | Eser, Bulent Kaplan, Bunyamin Unal, Ali Canoz, Ozlem Altuntas, Fevzi Sari, H. Ismail. Er, Ozlem Ozkan, Metin Kucuk, Can Arar, Makbule Gursoy, Sebnem Cetin, Mustafa |
author_sort | Eser, Bulent |
collection | PubMed |
description | Primary gastrointestinal lymphoma is a common presentation of non-Hodgkin's lymphoma. The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathologic characteristics and the therapeutic outcome of primary gastrointestinal non-Hodgkin's lymphoma. We carried out a retrospective analysis of 74 patients who were presented to our center with histopathological diagnosis of primary gastro-intestinal non-Hodgkin's lymphoma between 1990 and 2001. All patients have been staged according to Lugano Staging System. For histopathological classification, International Working Formulation was applied. The treatment choice concerning the surgical or non-surgical management was decided by the initially acting physician. Treatment modalities were compared using the parameters of age, sex, histopathological results, stage, and the site of disease. Of the 74 patients, 31 were female and 43 were male, with a median age of 49 years (range 15-80). The stomach was the most common primary site and was seen in 51 of 74 patients (68.9%). The intermediate and high grade lymphomas constituted 91.9% of the all cases. In a median follow-up of 29 months (range 2-128), 20 out of 74 patients died. There was a three year overall survival rate in 65.4% of all patients. The three year overall survival rate was better in stage I and II1 patients who were treated with surgery plus chemotherapy (+/-RT) than those treated with chemotherapy alone (93.7% vs. 55.6%, p < 0.05). The stage and presence of B symptoms affected the disease free survival and overall survival significantly, but the histopathologic grade only affected the overall survival. On the basis of these results, we suggest that surgical resection is necessary before chemotherapy in early stage (stage I and II1) patients with gastrointestinal non-Hodgkin's lymphomas because of the significant survival advantage it would bring to the patient. |
format | Text |
id | pubmed-2687578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26875782009-06-04 Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey Eser, Bulent Kaplan, Bunyamin Unal, Ali Canoz, Ozlem Altuntas, Fevzi Sari, H. Ismail. Er, Ozlem Ozkan, Metin Kucuk, Can Arar, Makbule Gursoy, Sebnem Cetin, Mustafa Yonsei Med J Original Article Primary gastrointestinal lymphoma is a common presentation of non-Hodgkin's lymphoma. The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathologic characteristics and the therapeutic outcome of primary gastrointestinal non-Hodgkin's lymphoma. We carried out a retrospective analysis of 74 patients who were presented to our center with histopathological diagnosis of primary gastro-intestinal non-Hodgkin's lymphoma between 1990 and 2001. All patients have been staged according to Lugano Staging System. For histopathological classification, International Working Formulation was applied. The treatment choice concerning the surgical or non-surgical management was decided by the initially acting physician. Treatment modalities were compared using the parameters of age, sex, histopathological results, stage, and the site of disease. Of the 74 patients, 31 were female and 43 were male, with a median age of 49 years (range 15-80). The stomach was the most common primary site and was seen in 51 of 74 patients (68.9%). The intermediate and high grade lymphomas constituted 91.9% of the all cases. In a median follow-up of 29 months (range 2-128), 20 out of 74 patients died. There was a three year overall survival rate in 65.4% of all patients. The three year overall survival rate was better in stage I and II1 patients who were treated with surgery plus chemotherapy (+/-RT) than those treated with chemotherapy alone (93.7% vs. 55.6%, p < 0.05). The stage and presence of B symptoms affected the disease free survival and overall survival significantly, but the histopathologic grade only affected the overall survival. On the basis of these results, we suggest that surgical resection is necessary before chemotherapy in early stage (stage I and II1) patients with gastrointestinal non-Hodgkin's lymphomas because of the significant survival advantage it would bring to the patient. Yonsei University College of Medicine 2006-02-28 2006-02-28 /pmc/articles/PMC2687578/ /pubmed/16502482 http://dx.doi.org/10.3349/ymj.2006.47.1.22 Text en Copyright © 2006 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Eser, Bulent Kaplan, Bunyamin Unal, Ali Canoz, Ozlem Altuntas, Fevzi Sari, H. Ismail. Er, Ozlem Ozkan, Metin Kucuk, Can Arar, Makbule Gursoy, Sebnem Cetin, Mustafa Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title | Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title_full | Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title_fullStr | Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title_full_unstemmed | Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title_short | Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey |
title_sort | clinicopathologic characteristics and therapeutic outcomes of primary gastrointestinal non-hodgkin's lymphomas in central anatolia, in turkey |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687578/ https://www.ncbi.nlm.nih.gov/pubmed/16502482 http://dx.doi.org/10.3349/ymj.2006.47.1.22 |
work_keys_str_mv | AT eserbulent clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT kaplanbunyamin clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT unalali clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT canozozlem clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT altuntasfevzi clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT sarihismail clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT erozlem clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT ozkanmetin clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT kucukcan clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT ararmakbule clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT gursoysebnem clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey AT cetinmustafa clinicopathologiccharacteristicsandtherapeuticoutcomesofprimarygastrointestinalnonhodgkinslymphomasincentralanatoliainturkey |