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Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch

Systemic capillary leak syndrome (SCLS) is a condition that's caused by the shift of fluid and protein from the intravascular space to the interstitial space as a result of repetitive episodes of capillary hyperpermeability. The pathogenesis of SCLS is still unclear, but there's recently b...

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Autores principales: Lee, Young Seok, Kim, Sun Young, Kwon, Chin Woo, Song, Hae Geun, Lee, Young Kyung, Kim, Hyo Jung, Zang, Dae Young
Formato: Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687610/
https://www.ncbi.nlm.nih.gov/pubmed/17616032
http://dx.doi.org/10.3904/kjim.2007.22.2.130
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author Lee, Young Seok
Kim, Sun Young
Kwon, Chin Woo
Song, Hae Geun
Lee, Young Kyung
Kim, Hyo Jung
Zang, Dae Young
author_facet Lee, Young Seok
Kim, Sun Young
Kwon, Chin Woo
Song, Hae Geun
Lee, Young Kyung
Kim, Hyo Jung
Zang, Dae Young
author_sort Lee, Young Seok
collection PubMed
description Systemic capillary leak syndrome (SCLS) is a condition that's caused by the shift of fluid and protein from the intravascular space to the interstitial space as a result of repetitive episodes of capillary hyperpermeability. The pathogenesis of SCLS is still unclear, but there's recently been a report showing this syndrome in association with monoclonal gammopathy. This syndrome can be a fatal disease because cardiovascular collapse can occur in the initial capillary leak phase. Although theophylline, diuretics, terbutaline, steroids, calcium antagonist, Ginkgo biloba extracts and plasmapheresis have been suggested as medication, none of them have been proven to be effective. Considering that this disease is self-limiting, conservative treatment in the acute phase is believed to be very important. Because hypoalbuminemia is very a common manifestation of SCLS, Pentastarch, which has a higher molecular weight than albumin, could be efficient to prevent cardiovascular collapse. We used 10% Pentastarch during the acute SCLS attacks of 2 patients and the patients both showed a dramatic response. Pentastarch may be helpful to treat SCLS in its initial capillary leak phase by the elevating blood pressure, and this might contribute to somewhat decreasing the acute mortality of SCLS.
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spelling pubmed-26876102009-06-15 Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch Lee, Young Seok Kim, Sun Young Kwon, Chin Woo Song, Hae Geun Lee, Young Kyung Kim, Hyo Jung Zang, Dae Young Korean J Intern Med Case Report Systemic capillary leak syndrome (SCLS) is a condition that's caused by the shift of fluid and protein from the intravascular space to the interstitial space as a result of repetitive episodes of capillary hyperpermeability. The pathogenesis of SCLS is still unclear, but there's recently been a report showing this syndrome in association with monoclonal gammopathy. This syndrome can be a fatal disease because cardiovascular collapse can occur in the initial capillary leak phase. Although theophylline, diuretics, terbutaline, steroids, calcium antagonist, Ginkgo biloba extracts and plasmapheresis have been suggested as medication, none of them have been proven to be effective. Considering that this disease is self-limiting, conservative treatment in the acute phase is believed to be very important. Because hypoalbuminemia is very a common manifestation of SCLS, Pentastarch, which has a higher molecular weight than albumin, could be efficient to prevent cardiovascular collapse. We used 10% Pentastarch during the acute SCLS attacks of 2 patients and the patients both showed a dramatic response. Pentastarch may be helpful to treat SCLS in its initial capillary leak phase by the elevating blood pressure, and this might contribute to somewhat decreasing the acute mortality of SCLS. The Korean Association of Internal Medicine 2007-06 2007-06-30 /pmc/articles/PMC2687610/ /pubmed/17616032 http://dx.doi.org/10.3904/kjim.2007.22.2.130 Text en Copyright © 2007 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Young Seok
Kim, Sun Young
Kwon, Chin Woo
Song, Hae Geun
Lee, Young Kyung
Kim, Hyo Jung
Zang, Dae Young
Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title_full Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title_fullStr Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title_full_unstemmed Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title_short Two Cases of Systemic Capillary Leak Syndrome that were Treated with Pentastarch
title_sort two cases of systemic capillary leak syndrome that were treated with pentastarch
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687610/
https://www.ncbi.nlm.nih.gov/pubmed/17616032
http://dx.doi.org/10.3904/kjim.2007.22.2.130
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