The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin

The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition...

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Detalles Bibliográficos
Autor principal: Schnitt, Stuart J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687714/
https://www.ncbi.nlm.nih.gov/pubmed/19291276
http://dx.doi.org/10.1186/bcr2228
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author Schnitt, Stuart J
author_facet Schnitt, Stuart J
author_sort Schnitt, Stuart J
collection PubMed
description The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.
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spelling pubmed-26877142009-05-29 The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin Schnitt, Stuart J Breast Cancer Res Editorial The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard. BioMed Central 2009 2009-02-27 /pmc/articles/PMC2687714/ /pubmed/19291276 http://dx.doi.org/10.1186/bcr2228 Text en Copyright © 2009 BioMed Central Ltd
spellingShingle Editorial
Schnitt, Stuart J
The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title_full The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title_fullStr The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title_full_unstemmed The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title_short The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
title_sort transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687714/
https://www.ncbi.nlm.nih.gov/pubmed/19291276
http://dx.doi.org/10.1186/bcr2228
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