Cargando…

Lipid Rafts and Clathrin Cooperate in the Internalization of PrP(C) in Epithelial FRT Cells

BACKGROUND: The cellular prion protein (PrP(C)) plays a key role in the pathogenesis of Transmissible Spongiform Encephalopathies in which the protein undergoes post-translational conversion to the infectious form (PrP(Sc)). Although endocytosis appears to be required for this conversion, the mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarnataro, Daniela, Caputo, Anna, Casanova, Philippe, Puri, Claudia, Paladino, Simona, Tivodar, Simona S., Campana, Vincenza, Tacchetti, Carlo, Zurzolo, Chiara
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688078/ https://www.ncbi.nlm.nih.gov/pubmed/19503793 http://dx.doi.org/10.1371/journal.pone.0005829

Ejemplares similares

Doppel and PrP(C) co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells
por: Caputo, Anna, et al.
Publicado: (2009)

Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins
por: Paladino, Simona, et al.
Publicado: (2004)

N-Glycosylation instead of cholesterol mediates oligomerization and apical sorting of GPI-APs in FRT cells
por: Imjeti, Naga Salaija, et al.
Publicado: (2011)

Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria
por: Guizzunti, Gianni, et al.
Publicado: (2015)

PrP(C) Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells
por: Arkhipenko, Alexander, et al.
Publicado: (2016)

The generation and characterization of novel Col1a1(FRT-Cre-ER-T2-FRT) and Col1a1(FRT-STOP-FRT-Cre-ER-T2) mice for sequential mutagenesis
por: Zhang, Minsi, et al.
Publicado: (2015)

Retraction: The generation and characterization of novel Col1a1(FRT-Cre-ER-T2-FRT) and Col1a1(FRT-STOP-FRT-Cre-ER-T2) mice for sequential mutagenesis
por: Zhang, Minsi, et al.
Publicado: (2016)

Retrograde Transport by Clathrin-Coated Vesicles is Involved in Intracellular Transport of PrP(Sc) in Persistently Prion-Infected Cells
por: Yamasaki, Takeshi, et al.
Publicado: (2018)

Live imaging of prions reveals nascent PrP(Sc) in cell-surface, raft-associated amyloid strings and webs
por: Rouvinski, Alexander, et al.
Publicado: (2014)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

Emerging roles of the cellular prion protein (PrP(C)) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology
por: Limone, Adriana, et al.
Publicado: (2023)

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

PrP Expression, PrP(Sc) Accumulation and Innervation of Splenic Compartments in Sheep Experimentally Infected with Scrapie
por: Sørby, Randi, et al.
Publicado: (2009)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

Introducing FRT-flanked p53 mice
Publicado: (2012)

Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations
por: Man, Wing-Young N, et al.
Publicado: (2007)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity
por: Luise, Chiara, et al.
Publicado: (2012)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
por: Barron, Rona M., et al.
Publicado: (2016)

Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis
por: Sevillano, Alejandro M., et al.
Publicado: (2018)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo
por: Pepe, Anna, et al.
Publicado: (2017)

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR
por: Cortese, Katia, et al.
Publicado: (2008)

Na(+)/K(+)-ATPase Is Present in Scrapie-Associated Fibrils, Modulates PrP Misfolding In Vitro and Links PrP Function and Dysfunction
por: Graham, James F., et al.
Publicado: (2011)

Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics
por: Jetha, Nahid N., et al.
Publicado: (2013)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer
por: Pocanschi, Cosmin L., et al.
Publicado: (2013)

PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2013)

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrP(res) in heterozygous scrapie positive goats
por: Mazza, Maria, et al.
Publicado: (2017)

Enhancement of binding avidity by bivalent binding enables PrP(Sc)-specific detection by anti-PrP monoclonal antibody 132
por: Suzuki, Akio, et al.
Publicado: (2019)

Species and Strain Glycosylation Patterns of PrP(Sc)
por: Xanthopoulos, Konstantinos, et al.
Publicado: (2009)

Regulation of PrP(C) signaling and processing by dimerization
por: Roucou, Xavier
Publicado: (2014)

PrP(C) from stem cells to cancer
por: Martin-Lannerée, Séverine, et al.
Publicado: (2014)

PrP charge structure encodes interdomain interactions
por: Martínez, Javier, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7bl6jq0e1u70hqn5cs7cvutq2l