Comparative Genome-Wide Screening Identifies a Conserved Doxorubicin Repair Network That Is Diploid Specific in Saccharomyces cerevisiae

The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion strains in which exposure to DOX was lethal or sever...

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Detalles Bibliográficos
Autores principales: Westmoreland, Tammy J., Wickramasekara, Sajith M., Guo, Andrew Y., Selim, Alice L., Winsor, Tiffany S., Greenleaf, Arno L., Blackwell, Kimberly L., Olson, John A., Marks, Jeffrey R., Bennett, Craig B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688081/
https://www.ncbi.nlm.nih.gov/pubmed/19503795
http://dx.doi.org/10.1371/journal.pone.0005830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688081/
https://www.ncbi.nlm.nih.gov/pubmed/19503795
http://dx.doi.org/10.1371/journal.pone.0005830

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