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Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

INTRODUCTION: Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI). Present models of VILI use exceptionally large tidal volumes, causing gross lung injury and haemodynamic shock. In addition, animals are ventilated for a relative short period of time and only after a 'pr...

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Detalles Bibliográficos
Autores principales:	Wolthuis, Esther K, Vlaar, Alexander PJ, Choi, Goda, Roelofs, Joris JTH, Juffermans, Nicole P, Schultz, Marcus J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688111/ https://www.ncbi.nlm.nih.gov/pubmed/19152704 http://dx.doi.org/10.1186/cc7688

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