Cargando…

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

INTRODUCTION: Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The present study investigated the effect of complement C5a blockade in preventing BBB damage and pituitary dysfunction durin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flierl, Michael A, Stahel, Philip F, Rittirsch, Daniel, Huber-Lang, Markus, Niederbichler, Andreas D, Hoesel, L Marco, Touban, Basel M, Morgan, Steven J, Smith, Wade R, Ward, Peter A, Ipaktchi, Kyros
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688129/ https://www.ncbi.nlm.nih.gov/pubmed/19196477 http://dx.doi.org/10.1186/cc7710

Ejemplares similares

Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis
por: Flierl, Michael A, et al.
Publicado: (2011)

Bench-to-bedside review: Burn-induced cerebral inflammation – a neglected entity?
por: Flierl, Michael A, et al.
Publicado: (2009)

Complement in Human Disease
por: Flierl, Michael A., et al.
Publicado: (2013)

An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction
por: Niederbichler, Andreas D., et al.
Publicado: (2006)

Unrecognized hand ischemia after intraarterial drug injection: successful management of a "near miss" event
por: Ipaktchi, Kyros, et al.
Publicado: (2008)

Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice
por: Stahel, Philip F, et al.
Publicado: (2009)

The Complement Anaphylatoxin C5a Induces Apoptosis in Adrenomedullary Cells during Experimental Sepsis
por: Flierl, Michael A., et al.
Publicado: (2008)

Pathophysiology of septic encephalopathy - an unsolved puzzle
por: Flierl, Michael A, et al.
Publicado: (2010)

Vascular injuries after minor blunt upper extremity trauma: pitfalls in the recognition and diagnosis of potential "near miss" injuries
por: Bravman, Jonathan T, et al.
Publicado: (2008)

Role of Complement in Multiorgan Failure
por: Rittirsch, Daniel, et al.
Publicado: (2012)

Burn-Induced Organ Dysfunction: Vagus Nerve Stimulation Improves Cardiac Function
por: Niederbichler, Andreas D., et al.
Publicado: (2010)

Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation
por: Leinhase, Iris, et al.
Publicado: (2006)

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"?
por: Neher, Miriam D, et al.
Publicado: (2011)

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

Intravenous immunoglobulins prevent breakdown of the blood-brain barrier in experimental sepsis
por: Esen, F, et al.
Publicado: (2010)

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

Current concepts for oil decontamination of crush injuries: a review
por: Karimkhani, Chante, et al.
Publicado: (2014)

Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown
por: Kim, Jong-Heon, et al.
Publicado: (2021)

Severe mycosis as a rare infection after a corn auger injury of the hand: a case report
por: Bowles, Richard J, et al.
Publicado: (2015)

Reconstruction of an emergency thoracotomy wound with free rectus abdominis flap: Anatomic and radiologic basis for the surgical technique
por: Gilman, Kaitlyn, et al.
Publicado: (2010)

Role of Complement and Histones in Sepsis
por: Zetoune, Firas S., et al.
Publicado: (2020)

Alteration of complement hemolytic activity in different trauma and sepsis models
por: Ehrnthaller, Christian, et al.
Publicado: (2012)

Current surgical instrument labeling techniques may increase the risk of unintentionally retained foreign objects: a hypothesis
por: Ipaktchi, Kyros, et al.
Publicado: (2013)

Breakdown of the Blood–Retinal Barrier
por: Vinores, S.A.
Publicado: (2010)

Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis
por: Mannes, Marco, et al.
Publicado: (2021)

Sepsis, complement and the dysregulated inflammatory response
por: Ward, Peter A, et al.
Publicado: (2009)

Retained palmar foreign body presenting as a late hand infection: proposed diagnostic algorithm to detect radiolucent objects
por: Ipaktchi, Kyros, et al.
Publicado: (2013)

Manipulation of the Complement System for Benefit in Sepsis
por: Ward, Peter A., et al.
Publicado: (2012)

Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response
por: Flierl, Michael A., et al.
Publicado: (2009)

Molecular mechanisms and management of traumatic brain injury – missing the link?
por: Flierl, Michael A, et al.
Publicado: (2009)

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction
por: Nation, Daniel A., et al.
Publicado: (2019)

Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice
por: Leinhase, Iris, et al.
Publicado: (2007)

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease?
por: Flierl, Michael A, et al.
Publicado: (2011)

Breakdown of the Endothelial Barrier Function in Tumor Cell Transmigration
por: Mierke, Claudia Tanja, et al.
Publicado: (2008)

Complexity of complement activation in sepsis
por: Markiewski, Maciej M, et al.
Publicado: (2008)

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
por: Skjeflo, Espen W., et al.
Publicado: (2015)

The Cerebral Effect of Ammonia in Brain Aging: Blood–Brain Barrier Breakdown, Mitochondrial Dysfunction, and Neuroinflammation
por: Jo, Danbi, et al.
Publicado: (2021)

Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease
por: Lin, Zixuan, et al.
Publicado: (2021)

Breakdown of supersaturation barrier links protein folding to amyloid formation
por: Noji, Masahiro, et al.
Publicado: (2021)

Blood–Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models
por: Brandl, Sarah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_54mk0q83ov3n680gj0qpc7gnlm