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Characteristics and outcomes of cancer patients in European ICUs
INTRODUCTION: Increasing numbers of cancer patients are being admitted to the intensive care unit (ICU), either for cancer-related complications or treatment-associated side effects, yet there are relatively few data concerning the epidemiology and prognosis of cancer patients admitted to general IC...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688132/ https://www.ncbi.nlm.nih.gov/pubmed/19200368 http://dx.doi.org/10.1186/cc7713 |
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author | Taccone, Fabio Silvio Artigas, Antonio A Sprung, Charles L Moreno, Rui Sakr, Yasser Vincent, Jean-Louis |
author_facet | Taccone, Fabio Silvio Artigas, Antonio A Sprung, Charles L Moreno, Rui Sakr, Yasser Vincent, Jean-Louis |
author_sort | Taccone, Fabio Silvio |
collection | PubMed |
description | INTRODUCTION: Increasing numbers of cancer patients are being admitted to the intensive care unit (ICU), either for cancer-related complications or treatment-associated side effects, yet there are relatively few data concerning the epidemiology and prognosis of cancer patients admitted to general ICUs. The aim of this study was to assess the characteristics of critically ill cancer patients, and to evaluate their prognosis. METHODS: This was a substudy of the Sepsis Occurrence in Acutely Ill Patients (SOAP) study, a cohort, multicentre, observational study that included data from all adult patients admitted to one of 198 participating ICUs from 24 European countries during the study period. Patients were followed up until death, hospital discharge or for 60 days. RESULTS: Of the 3147 patients enrolled in the SOAP study, 473 (15%) had a malignancy, 404 (85%) had solid tumours and 69 (15%) had haematological cancer. Patients with solid cancers had the same severity of illness as the non-cancer population, but were older, more likely to be a surgical admission and had a higher frequency of sepsis. Patients with haematological cancer were more severely ill and more commonly had sepsis, acute lung injury/acute respiratory distress syndrome, and renal failure than patients with other malignancies; these patients also had the highest hospital mortality rate (58%). The outcome of all cancer patients was comparable with that in the non-cancer population, with a 27% hospital mortality rate. However, in the subset of patients with more than three failing organs, more than 75% of patients with cancer died compared with about 50% of patients without cancer (p = 0.01). CONCLUSIONS: In this large European study, patients with cancer were more often admitted to the ICU for sepsis and respiratory complications than other ICU patients. Overall, the outcome of patients with solid cancer was similar to that of ICU patients without cancer, whereas patients with haematological cancer had a worse outcome. |
format | Text |
id | pubmed-2688132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26881322009-05-30 Characteristics and outcomes of cancer patients in European ICUs Taccone, Fabio Silvio Artigas, Antonio A Sprung, Charles L Moreno, Rui Sakr, Yasser Vincent, Jean-Louis Crit Care Research INTRODUCTION: Increasing numbers of cancer patients are being admitted to the intensive care unit (ICU), either for cancer-related complications or treatment-associated side effects, yet there are relatively few data concerning the epidemiology and prognosis of cancer patients admitted to general ICUs. The aim of this study was to assess the characteristics of critically ill cancer patients, and to evaluate their prognosis. METHODS: This was a substudy of the Sepsis Occurrence in Acutely Ill Patients (SOAP) study, a cohort, multicentre, observational study that included data from all adult patients admitted to one of 198 participating ICUs from 24 European countries during the study period. Patients were followed up until death, hospital discharge or for 60 days. RESULTS: Of the 3147 patients enrolled in the SOAP study, 473 (15%) had a malignancy, 404 (85%) had solid tumours and 69 (15%) had haematological cancer. Patients with solid cancers had the same severity of illness as the non-cancer population, but were older, more likely to be a surgical admission and had a higher frequency of sepsis. Patients with haematological cancer were more severely ill and more commonly had sepsis, acute lung injury/acute respiratory distress syndrome, and renal failure than patients with other malignancies; these patients also had the highest hospital mortality rate (58%). The outcome of all cancer patients was comparable with that in the non-cancer population, with a 27% hospital mortality rate. However, in the subset of patients with more than three failing organs, more than 75% of patients with cancer died compared with about 50% of patients without cancer (p = 0.01). CONCLUSIONS: In this large European study, patients with cancer were more often admitted to the ICU for sepsis and respiratory complications than other ICU patients. Overall, the outcome of patients with solid cancer was similar to that of ICU patients without cancer, whereas patients with haematological cancer had a worse outcome. BioMed Central 2009 2009-02-06 /pmc/articles/PMC2688132/ /pubmed/19200368 http://dx.doi.org/10.1186/cc7713 Text en Copyright © 2009 Taccone et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Taccone, Fabio Silvio Artigas, Antonio A Sprung, Charles L Moreno, Rui Sakr, Yasser Vincent, Jean-Louis Characteristics and outcomes of cancer patients in European ICUs |
title | Characteristics and outcomes of cancer patients in European ICUs |
title_full | Characteristics and outcomes of cancer patients in European ICUs |
title_fullStr | Characteristics and outcomes of cancer patients in European ICUs |
title_full_unstemmed | Characteristics and outcomes of cancer patients in European ICUs |
title_short | Characteristics and outcomes of cancer patients in European ICUs |
title_sort | characteristics and outcomes of cancer patients in european icus |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688132/ https://www.ncbi.nlm.nih.gov/pubmed/19200368 http://dx.doi.org/10.1186/cc7713 |
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