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Antiallodynic Effects of Acupuncture in Neuropathic Rats
Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this s...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Yonsei University College of Medicine
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688155/ https://www.ncbi.nlm.nih.gov/pubmed/16807985 http://dx.doi.org/10.3349/ymj.2006.47.3.359 |
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author | Cha, Myeoung Hoon Choi, Ji Soo Bai, Sun Joon Shim, Insop Lee, Hye-Jung Choi, Sun Mi Lee, Bae Hwan |
author_facet | Cha, Myeoung Hoon Choi, Ji Soo Bai, Sun Joon Shim, Insop Lee, Hye-Jung Choi, Sun Mi Lee, Bae Hwan |
author_sort | Cha, Myeoung Hoon |
collection | PubMed |
description | Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this study was to investigate the anti-allodynic effects of acupuncture through behavioral and electrophysiological examinations. Male Sprague-Dawley rats were subjected to neuropathic surgery consisting of a tight ligation and transection of the left tibial and sural nerves, under pentobarbital anesthesia. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group. Behavioral tests for mechanical allodynia and cold allodynia were performed for up to two weeks postoperatively. Extracellular electrophysiological recordings were made from the dorsal roots using platinum wire electrodes. Mechanical and cold allodynia were significantly reduced after acupuncture treatment at the Zusanli and Yinlingquan acupoints, respectively. Electrophysiological neural responses to von Frey and acetone tests were also reduced after acupuncture at the same two acupoints. These results suggest that acupuncture may be beneficial in relieving neuropathic pain. |
format | Text |
id | pubmed-2688155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26881552009-06-04 Antiallodynic Effects of Acupuncture in Neuropathic Rats Cha, Myeoung Hoon Choi, Ji Soo Bai, Sun Joon Shim, Insop Lee, Hye-Jung Choi, Sun Mi Lee, Bae Hwan Yonsei Med J Original Article Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this study was to investigate the anti-allodynic effects of acupuncture through behavioral and electrophysiological examinations. Male Sprague-Dawley rats were subjected to neuropathic surgery consisting of a tight ligation and transection of the left tibial and sural nerves, under pentobarbital anesthesia. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group. Behavioral tests for mechanical allodynia and cold allodynia were performed for up to two weeks postoperatively. Extracellular electrophysiological recordings were made from the dorsal roots using platinum wire electrodes. Mechanical and cold allodynia were significantly reduced after acupuncture treatment at the Zusanli and Yinlingquan acupoints, respectively. Electrophysiological neural responses to von Frey and acetone tests were also reduced after acupuncture at the same two acupoints. These results suggest that acupuncture may be beneficial in relieving neuropathic pain. Yonsei University College of Medicine 2006-06-30 2006-06-30 /pmc/articles/PMC2688155/ /pubmed/16807985 http://dx.doi.org/10.3349/ymj.2006.47.3.359 Text en Copyright © 2006 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cha, Myeoung Hoon Choi, Ji Soo Bai, Sun Joon Shim, Insop Lee, Hye-Jung Choi, Sun Mi Lee, Bae Hwan Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title | Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title_full | Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title_fullStr | Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title_full_unstemmed | Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title_short | Antiallodynic Effects of Acupuncture in Neuropathic Rats |
title_sort | antiallodynic effects of acupuncture in neuropathic rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688155/ https://www.ncbi.nlm.nih.gov/pubmed/16807985 http://dx.doi.org/10.3349/ymj.2006.47.3.359 |
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