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Antiallodynic Effects of Acupuncture in Neuropathic Rats

Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this s...

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Autores principales: Cha, Myeoung Hoon, Choi, Ji Soo, Bai, Sun Joon, Shim, Insop, Lee, Hye-Jung, Choi, Sun Mi, Lee, Bae Hwan
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688155/
https://www.ncbi.nlm.nih.gov/pubmed/16807985
http://dx.doi.org/10.3349/ymj.2006.47.3.359
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author Cha, Myeoung Hoon
Choi, Ji Soo
Bai, Sun Joon
Shim, Insop
Lee, Hye-Jung
Choi, Sun Mi
Lee, Bae Hwan
author_facet Cha, Myeoung Hoon
Choi, Ji Soo
Bai, Sun Joon
Shim, Insop
Lee, Hye-Jung
Choi, Sun Mi
Lee, Bae Hwan
author_sort Cha, Myeoung Hoon
collection PubMed
description Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this study was to investigate the anti-allodynic effects of acupuncture through behavioral and electrophysiological examinations. Male Sprague-Dawley rats were subjected to neuropathic surgery consisting of a tight ligation and transection of the left tibial and sural nerves, under pentobarbital anesthesia. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group. Behavioral tests for mechanical allodynia and cold allodynia were performed for up to two weeks postoperatively. Extracellular electrophysiological recordings were made from the dorsal roots using platinum wire electrodes. Mechanical and cold allodynia were significantly reduced after acupuncture treatment at the Zusanli and Yinlingquan acupoints, respectively. Electrophysiological neural responses to von Frey and acetone tests were also reduced after acupuncture at the same two acupoints. These results suggest that acupuncture may be beneficial in relieving neuropathic pain.
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spelling pubmed-26881552009-06-04 Antiallodynic Effects of Acupuncture in Neuropathic Rats Cha, Myeoung Hoon Choi, Ji Soo Bai, Sun Joon Shim, Insop Lee, Hye-Jung Choi, Sun Mi Lee, Bae Hwan Yonsei Med J Original Article Peripheral nerve injury often results in abnormal neuropathic pain such as allodynia or hyperalgesia. Acupuncture, a traditional Oriental medicine, has been used to relieve pain and related symptoms. However, the efficiency of acupuncture in relieving neuropathic pain is not clear. The aim of this study was to investigate the anti-allodynic effects of acupuncture through behavioral and electrophysiological examinations. Male Sprague-Dawley rats were subjected to neuropathic surgery consisting of a tight ligation and transection of the left tibial and sural nerves, under pentobarbital anesthesia. The acupuncture experiment consisted of four different groups, one treated at each of three different acupoints (Zusanli (ST36), Yinlingquan (SP9), and a sham-acupoint) and a control group. Behavioral tests for mechanical allodynia and cold allodynia were performed for up to two weeks postoperatively. Extracellular electrophysiological recordings were made from the dorsal roots using platinum wire electrodes. Mechanical and cold allodynia were significantly reduced after acupuncture treatment at the Zusanli and Yinlingquan acupoints, respectively. Electrophysiological neural responses to von Frey and acetone tests were also reduced after acupuncture at the same two acupoints. These results suggest that acupuncture may be beneficial in relieving neuropathic pain. Yonsei University College of Medicine 2006-06-30 2006-06-30 /pmc/articles/PMC2688155/ /pubmed/16807985 http://dx.doi.org/10.3349/ymj.2006.47.3.359 Text en Copyright © 2006 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cha, Myeoung Hoon
Choi, Ji Soo
Bai, Sun Joon
Shim, Insop
Lee, Hye-Jung
Choi, Sun Mi
Lee, Bae Hwan
Antiallodynic Effects of Acupuncture in Neuropathic Rats
title Antiallodynic Effects of Acupuncture in Neuropathic Rats
title_full Antiallodynic Effects of Acupuncture in Neuropathic Rats
title_fullStr Antiallodynic Effects of Acupuncture in Neuropathic Rats
title_full_unstemmed Antiallodynic Effects of Acupuncture in Neuropathic Rats
title_short Antiallodynic Effects of Acupuncture in Neuropathic Rats
title_sort antiallodynic effects of acupuncture in neuropathic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688155/
https://www.ncbi.nlm.nih.gov/pubmed/16807985
http://dx.doi.org/10.3349/ymj.2006.47.3.359
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