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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally...

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Detalles Bibliográficos
Autores principales: Walmsley, Sarah R, Chilvers, Edwin R, Whyte, Moira KB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688173/
https://www.ncbi.nlm.nih.gov/pubmed/19435530
http://dx.doi.org/10.1186/ar2632
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author Walmsley, Sarah R
Chilvers, Edwin R
Whyte, Moira KB
author_facet Walmsley, Sarah R
Chilvers, Edwin R
Whyte, Moira KB
author_sort Walmsley, Sarah R
collection PubMed
description With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
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spelling pubmed-26881732009-10-21 Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function Walmsley, Sarah R Chilvers, Edwin R Whyte, Moira KB Arthritis Res Ther Review With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed. BioMed Central 2009 2009-04-21 /pmc/articles/PMC2688173/ /pubmed/19435530 http://dx.doi.org/10.1186/ar2632 Text en Copyright © 2009 BioMed Central Ltd
spellingShingle Review
Walmsley, Sarah R
Chilvers, Edwin R
Whyte, Moira KB
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title_full Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title_fullStr Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title_full_unstemmed Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title_short Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
title_sort hypoxia. hypoxia, hypoxia inducible factor and myeloid cell function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688173/
https://www.ncbi.nlm.nih.gov/pubmed/19435530
http://dx.doi.org/10.1186/ar2632
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