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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688173/ https://www.ncbi.nlm.nih.gov/pubmed/19435530 http://dx.doi.org/10.1186/ar2632 |
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author | Walmsley, Sarah R Chilvers, Edwin R Whyte, Moira KB |
author_facet | Walmsley, Sarah R Chilvers, Edwin R Whyte, Moira KB |
author_sort | Walmsley, Sarah R |
collection | PubMed |
description | With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed. |
format | Text |
id | pubmed-2688173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26881732009-10-21 Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function Walmsley, Sarah R Chilvers, Edwin R Whyte, Moira KB Arthritis Res Ther Review With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed. BioMed Central 2009 2009-04-21 /pmc/articles/PMC2688173/ /pubmed/19435530 http://dx.doi.org/10.1186/ar2632 Text en Copyright © 2009 BioMed Central Ltd |
spellingShingle | Review Walmsley, Sarah R Chilvers, Edwin R Whyte, Moira KB Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title_full | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title_fullStr | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title_full_unstemmed | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title_short | Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function |
title_sort | hypoxia. hypoxia, hypoxia inducible factor and myeloid cell function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688173/ https://www.ncbi.nlm.nih.gov/pubmed/19435530 http://dx.doi.org/10.1186/ar2632 |
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