Cargando…

Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis

INTRODUCTION: 15-Lipoxygenases and their metabolites have been shown to exhibit anti-inflammatory and immunomodulatory properties, but little is known regarding their expression and function in chondrocytes. The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chabane, Nadir, Zayed, Nadia, Benderdour, Mohamed, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Duval, Nicolas, Fahmi, Hassan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688191/ https://www.ncbi.nlm.nih.gov/pubmed/19296842 http://dx.doi.org/10.1186/ar2652

Ejemplares similares

Increased expression of lipocalin-type prostaglandin D(2 )synthase in osteoarthritic cartilage
por: Zayed, Nadia, et al.
Publicado: (2008)

Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes
por: Afif, Hassan, et al.
Publicado: (2007)

Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes
por: Nebbaki, Salwa Sarah, et al.
Publicado: (2012)

Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis
por: Ezzahra El Mansouri, Fatima, et al.
Publicado: (2012)

Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes
por: Nebbaki, Sarah S, et al.
Publicado: (2012)

Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes
por: Nebbaki, Sarah-Salwa, et al.
Publicado: (2012)

Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes
por: Zayed, N, et al.
Publicado: (2010)

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein
por: Maxis, Kelitha, et al.
Publicado: (2006)

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis
por: Ouhaddi, Yassine, et al.
Publicado: (2020)

Interleukin-1-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in human OA chondrocytes is associated with histone H3K4 methylation
por: Chabane, N, et al.
Publicado: (2010)

Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
por: El Mansouri, Fatima Ezzahra, et al.
Publicado: (2014)

Regulation of microsomal prostaglandin E(2 )synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
por: Chen, Shu-Huang, et al.
Publicado: (2010)

Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis
por: Najar, Mehdi, et al.
Publicado: (2020)

Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes
por: Afif, H, et al.
Publicado: (2007)

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
por: Tardif, Ginette, et al.
Publicado: (2009)

Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study
por: Boileau, Christelle, et al.
Publicado: (2007)

In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice
por: Paré, Frédéric, et al.
Publicado: (2020)

The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target
por: Li, Ying-Hua, et al.
Publicado: (2016)

Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative
por: Pelletier, Jean-Pierre, et al.
Publicado: (2018)

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis
por: Tardif, Ginette, et al.
Publicado: (2013)

The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man
por: Pelletier, Jean-Pierre, et al.
Publicado: (2002)

Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review
por: Martel-Pelletier, Johanne, et al.
Publicado: (2022)

Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cells
por: Najar, Mehdi, et al.
Publicado: (2020)

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow
por: Pelletier, Jean-Pierre, et al.
Publicado: (2006)

Prostaglandin D2 enhances interleukin -1beta- induced cyclooxygenase-2 expression in osteoarthritic cartilage
por: Zayed, N, et al.
Publicado: (2010)

Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis
por: Chen, Kaizhe, et al.
Publicado: (2017)

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
por: Tat, Steeve Kwan, et al.
Publicado: (2007)

Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis diagnosis and prognosis
por: Martel-Pelletier, Johanne, et al.
Publicado: (2023)

Implication of microRNA-140 in osteoarthritis
por: Martel-Pelletier, Johanne
Publicado: (2012)

In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis
por: Farrán, Aina, et al.
Publicado: (2018)

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers
por: Tardif, Ginette, et al.
Publicado: (2022)

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort
por: Dorais, Marc, et al.
Publicado: (2018)

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
por: Kwan Tat, Steeve, et al.
Publicado: (2009)

PPARγ ligands inhibit catabolic and inflammatory responses in articular joint cells
por: Fahmi, H, et al.
Publicado: (2003)

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
por: Vasheghani, Faezeh, et al.
Publicado: (2015)

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review
por: Martel-Pelletier, Johanne, et al.
Publicado: (2021)

A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature
por: Bonakdari, Hossein, et al.
Publicado: (2022)

Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury
por: Pelletier, Jean-Pierre, et al.
Publicado: (2023)

Abnormal osteogenesis in osteoarthritis: gone with the Wnt?
por: Lajeunesse, Daniel, et al.
Publicado: (2012)

Intra-articular corticosteroid knee injection induces a reduction in meniscal thickness with no treatment effect on cartilage volume: a case–control study
por: Pelletier, Jean-Pierre, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_15qbeumab4b4rbv78m8lkr1ggv