Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

INTRODUCTION: TNFα is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNFα activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFα-regulated gene expre...

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Detalles Bibliográficos
Autores principales: Rockel, Jason S, Bernier, Suzanne M, Leask, Andrew
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688239/
https://www.ncbi.nlm.nih.gov/pubmed/19144181
http://dx.doi.org/10.1186/ar2595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688239/
https://www.ncbi.nlm.nih.gov/pubmed/19144181
http://dx.doi.org/10.1186/ar2595

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