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Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

INTRODUCTION: TNFα is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNFα activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFα-regulated gene expre...

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Detalles Bibliográficos
Autores principales:	Rockel, Jason S, Bernier, Suzanne M, Leask, Andrew
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688239/ https://www.ncbi.nlm.nih.gov/pubmed/19144181 http://dx.doi.org/10.1186/ar2595

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