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Biomarkers in Acute Coronary Syndrome
BACKGROUND: Evaluation of patients who present to the hospital with acute undifferentiated chest pain or other symptoms and signs suggestive of Acute Coronary Syndrome (ACS) is often a clinical challenge. The initial assessment, requiring a focused history (including risk factors analysis), a physic...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688349/ https://www.ncbi.nlm.nih.gov/pubmed/19578525 |
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author | Loria, Valentina Leo, Milena Biasillo, Gina Dato, Ilaria Biasucci, Luigi M. |
author_facet | Loria, Valentina Leo, Milena Biasillo, Gina Dato, Ilaria Biasucci, Luigi M. |
author_sort | Loria, Valentina |
collection | PubMed |
description | BACKGROUND: Evaluation of patients who present to the hospital with acute undifferentiated chest pain or other symptoms and signs suggestive of Acute Coronary Syndrome (ACS) is often a clinical challenge. The initial assessment, requiring a focused history (including risk factors analysis), a physical examination, an electrocardiogram (EKG) and serum cardiac marker determination, is time-consuming and troublesome. Recent investigations have indicated that increases in biomarkers of necrosis, inflammation, ischemia and myocardial stretch may provide earlier assessment of overall patient risk, help in identifying the adequate diagnostic and therapeutic management for each patient and allow for prevention of substantial numbers of new events. APPROACH AND CONTENT: The purpose of this review is to provide an overview of the characteristics of several biomarkers that may have potential clinical utility to identify ACS patients. Patho-physiology, analytical and clinical characteristics have been evaluated for each marker, underlying the properties for potential routine clinical use. SUMMARY: The biomarkers discussed in this review are promising and might lead to improved diagnosis and risk stratification of patients with ACS, however their clinical application requires further studies. It is important to define their clinical role as diagnostic markers, their predictive value and the specificity, standardization and detection limits of the assays. |
format | Text |
id | pubmed-2688349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-26883492009-07-01 Biomarkers in Acute Coronary Syndrome Loria, Valentina Leo, Milena Biasillo, Gina Dato, Ilaria Biasucci, Luigi M. Biomark Insights Original Research BACKGROUND: Evaluation of patients who present to the hospital with acute undifferentiated chest pain or other symptoms and signs suggestive of Acute Coronary Syndrome (ACS) is often a clinical challenge. The initial assessment, requiring a focused history (including risk factors analysis), a physical examination, an electrocardiogram (EKG) and serum cardiac marker determination, is time-consuming and troublesome. Recent investigations have indicated that increases in biomarkers of necrosis, inflammation, ischemia and myocardial stretch may provide earlier assessment of overall patient risk, help in identifying the adequate diagnostic and therapeutic management for each patient and allow for prevention of substantial numbers of new events. APPROACH AND CONTENT: The purpose of this review is to provide an overview of the characteristics of several biomarkers that may have potential clinical utility to identify ACS patients. Patho-physiology, analytical and clinical characteristics have been evaluated for each marker, underlying the properties for potential routine clinical use. SUMMARY: The biomarkers discussed in this review are promising and might lead to improved diagnosis and risk stratification of patients with ACS, however their clinical application requires further studies. It is important to define their clinical role as diagnostic markers, their predictive value and the specificity, standardization and detection limits of the assays. Libertas Academica 2008-11-05 /pmc/articles/PMC2688349/ /pubmed/19578525 Text en © 2008 by the authors http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0) |
spellingShingle | Original Research Loria, Valentina Leo, Milena Biasillo, Gina Dato, Ilaria Biasucci, Luigi M. Biomarkers in Acute Coronary Syndrome |
title | Biomarkers in Acute Coronary Syndrome |
title_full | Biomarkers in Acute Coronary Syndrome |
title_fullStr | Biomarkers in Acute Coronary Syndrome |
title_full_unstemmed | Biomarkers in Acute Coronary Syndrome |
title_short | Biomarkers in Acute Coronary Syndrome |
title_sort | biomarkers in acute coronary syndrome |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688349/ https://www.ncbi.nlm.nih.gov/pubmed/19578525 |
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