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Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen
Carcinoembryonic antigen (CEA), highly expressed in many cancer types, is an important target for cancer diagnosis and therapy. Radionuclide-based imaging techniques (gamma camera, single photon emission computed tomography [SPECT] and positron emission tomography [PET]) have been extensively explor...
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Formato: | Texto |
Lenguaje: | English |
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Libertas Academica
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688357/ https://www.ncbi.nlm.nih.gov/pubmed/19578524 |
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author | Hong, Hao Sun, Jiangtao Cai, Weibo |
author_facet | Hong, Hao Sun, Jiangtao Cai, Weibo |
author_sort | Hong, Hao |
collection | PubMed |
description | Carcinoembryonic antigen (CEA), highly expressed in many cancer types, is an important target for cancer diagnosis and therapy. Radionuclide-based imaging techniques (gamma camera, single photon emission computed tomography [SPECT] and positron emission tomography [PET]) have been extensively explored for CEA-targeted cancer imaging both preclinically and clinically. Briefly, these studies can be divided into three major categories: antibody-based, antibody fragment-based and pretargeted imaging. Radiolabeled anti-CEA antibodies, reported the earliest among the three categories, typically gave suboptimal tumor contrast due to the prolonged circulation life time of intact antibodies. Subsequently, a number of engineered anti-CEA antibody fragments (e.g. Fab’, scFv, minibody, diabody and scFv-Fc) have been labeled with a variety of radioisotopes for CEA imaging, many of which have entered clinical investigation. CEA-Scan (a (99m)Tc-labeled anti-CEA Fab’ fragment) has already been approved by the United States Food and Drug Administration for cancer imaging. Meanwhile, pretargeting strategies have also been developed for CEA imaging which can give much better tumor contrast than the other two methods, if the system is designed properly. In this review article, we will summarize the current state-of-the-art of radionuclide-based cancer imaging targeting CEA. Generally, isotopes with short half-lives (e.g. (18)F and (99m)Tc) are more suitable for labeling small engineered antibody fragments while the isotopes with longer half-lives (e.g. (123)I and (111)In) are needed for antibody labeling to match its relatively long circulation half-life. With further improvement in tumor targeting efficacy and radiolabeling strategies, novel CEA-targeted agents may play an important role in cancer patient management, paving the way to “personalized medicine”. |
format | Text |
id | pubmed-2688357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-26883572009-07-01 Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen Hong, Hao Sun, Jiangtao Cai, Weibo Biomark Insights Original Research Carcinoembryonic antigen (CEA), highly expressed in many cancer types, is an important target for cancer diagnosis and therapy. Radionuclide-based imaging techniques (gamma camera, single photon emission computed tomography [SPECT] and positron emission tomography [PET]) have been extensively explored for CEA-targeted cancer imaging both preclinically and clinically. Briefly, these studies can be divided into three major categories: antibody-based, antibody fragment-based and pretargeted imaging. Radiolabeled anti-CEA antibodies, reported the earliest among the three categories, typically gave suboptimal tumor contrast due to the prolonged circulation life time of intact antibodies. Subsequently, a number of engineered anti-CEA antibody fragments (e.g. Fab’, scFv, minibody, diabody and scFv-Fc) have been labeled with a variety of radioisotopes for CEA imaging, many of which have entered clinical investigation. CEA-Scan (a (99m)Tc-labeled anti-CEA Fab’ fragment) has already been approved by the United States Food and Drug Administration for cancer imaging. Meanwhile, pretargeting strategies have also been developed for CEA imaging which can give much better tumor contrast than the other two methods, if the system is designed properly. In this review article, we will summarize the current state-of-the-art of radionuclide-based cancer imaging targeting CEA. Generally, isotopes with short half-lives (e.g. (18)F and (99m)Tc) are more suitable for labeling small engineered antibody fragments while the isotopes with longer half-lives (e.g. (123)I and (111)In) are needed for antibody labeling to match its relatively long circulation half-life. With further improvement in tumor targeting efficacy and radiolabeling strategies, novel CEA-targeted agents may play an important role in cancer patient management, paving the way to “personalized medicine”. Libertas Academica 2008-09-23 /pmc/articles/PMC2688357/ /pubmed/19578524 Text en © 2008 by the authors http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0) |
spellingShingle | Original Research Hong, Hao Sun, Jiangtao Cai, Weibo Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title | Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title_full | Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title_fullStr | Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title_full_unstemmed | Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title_short | Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen |
title_sort | radionuclide-based cancer imaging targeting the carcinoembryonic antigen |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688357/ https://www.ncbi.nlm.nih.gov/pubmed/19578524 |
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