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Alzheimer’s Disease, Diagnosis and the Need for Biomarkers

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of aging that presents with memory loss, disorientation, confusion and a reduction in cognitive ability. Although a definite diagnosis of the disorder can only be made post-mortem by histopathological analysis, a number of methods...

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Detalles Bibliográficos
Autores principales: Hooper, Claudie, Lovestone, Simon, Sainz-Fuertes, Ricardo
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688363/
https://www.ncbi.nlm.nih.gov/pubmed/19578515
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author Hooper, Claudie
Lovestone, Simon
Sainz-Fuertes, Ricardo
author_facet Hooper, Claudie
Lovestone, Simon
Sainz-Fuertes, Ricardo
author_sort Hooper, Claudie
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of aging that presents with memory loss, disorientation, confusion and a reduction in cognitive ability. Although a definite diagnosis of the disorder can only be made post-mortem by histopathological analysis, a number of methods are currently available for the in vivo assessment of AD including psycho-metric tests and neuro-imaging. However, these clinical assessments are relatively nonspecific and imaging is very costly. Genetic testing can be performed if familial AD is suspected, although such cases represent a very small minority of total AD cases. Apolipoprotein E genotype provides a measure for analysing the risk of developing AD, but does not act as an absolute predictive biomarker for AD. Therefore there is a need for an accurate, universal, specific and cost-effective biomarker to facilitate not only ante-mortem diagnosis of AD, but also to allow progression of the disease and response to therapy to be monitored. This is the ultimate goal that our group is pursuing through the pan-European AddNeuroMed project.
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spelling pubmed-26883632009-07-01 Alzheimer’s Disease, Diagnosis and the Need for Biomarkers Hooper, Claudie Lovestone, Simon Sainz-Fuertes, Ricardo Biomark Insights Original Research Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of aging that presents with memory loss, disorientation, confusion and a reduction in cognitive ability. Although a definite diagnosis of the disorder can only be made post-mortem by histopathological analysis, a number of methods are currently available for the in vivo assessment of AD including psycho-metric tests and neuro-imaging. However, these clinical assessments are relatively nonspecific and imaging is very costly. Genetic testing can be performed if familial AD is suspected, although such cases represent a very small minority of total AD cases. Apolipoprotein E genotype provides a measure for analysing the risk of developing AD, but does not act as an absolute predictive biomarker for AD. Therefore there is a need for an accurate, universal, specific and cost-effective biomarker to facilitate not only ante-mortem diagnosis of AD, but also to allow progression of the disease and response to therapy to be monitored. This is the ultimate goal that our group is pursuing through the pan-European AddNeuroMed project. Libertas Academica 2008-05-27 /pmc/articles/PMC2688363/ /pubmed/19578515 Text en © 2008 by the authors http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Original Research
Hooper, Claudie
Lovestone, Simon
Sainz-Fuertes, Ricardo
Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title_full Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title_fullStr Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title_full_unstemmed Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title_short Alzheimer’s Disease, Diagnosis and the Need for Biomarkers
title_sort alzheimer’s disease, diagnosis and the need for biomarkers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688363/
https://www.ncbi.nlm.nih.gov/pubmed/19578515
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