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Proteomic Biomarkers of Atherosclerosis

SUMMARY: Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarke...

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Autores principales: Vivanco, F., Padial, L.R., Darde, V.M., de la Cuesta, F., Alvarez-Llamas, G., Diaz-Prieto, Natacha, Barderas, M.G.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688368/
https://www.ncbi.nlm.nih.gov/pubmed/19578499
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author Vivanco, F.
Padial, L.R.
Darde, V.M.
de la Cuesta, F.
Alvarez-Llamas, G.
Diaz-Prieto, Natacha
Barderas, M.G.
author_facet Vivanco, F.
Padial, L.R.
Darde, V.M.
de la Cuesta, F.
Alvarez-Llamas, G.
Diaz-Prieto, Natacha
Barderas, M.G.
author_sort Vivanco, F.
collection PubMed
description SUMMARY: Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new proteins in health and disease and is playing a significant role in the development of new diagnostic tools in cardiovascular diagnosis and prognosis. This review provides an overview of progress in applying proteomics to atherosclerosis. First, we describe novel proteins identified analysing atherosclerotic plaques directly. Careful analysis of proteins within the atherosclerotic vascular tissue can provide a repertoire of proteins involved in vascular remodelling and atherogenesis. Second, we discuss recent data concerning proteins secreted by atherosclerotic plaques. The definition of the atheroma plaque secretome resides in that proteins secreted by arteries can be very good candidates of novel biomarkers. Finally we describe proteins that have been differentially expressed (versus controls) by individual cells which constitute atheroma plaques (endothelial cells, vascular smooth muscle cells, macrophages and foam cells) as well as by circulating cells (monocytes, platelets) or novel biomarkers present in plasma.
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spelling pubmed-26883682009-07-01 Proteomic Biomarkers of Atherosclerosis Vivanco, F. Padial, L.R. Darde, V.M. de la Cuesta, F. Alvarez-Llamas, G. Diaz-Prieto, Natacha Barderas, M.G. Biomark Insights Original Research SUMMARY: Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The “omics” tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new proteins in health and disease and is playing a significant role in the development of new diagnostic tools in cardiovascular diagnosis and prognosis. This review provides an overview of progress in applying proteomics to atherosclerosis. First, we describe novel proteins identified analysing atherosclerotic plaques directly. Careful analysis of proteins within the atherosclerotic vascular tissue can provide a repertoire of proteins involved in vascular remodelling and atherogenesis. Second, we discuss recent data concerning proteins secreted by atherosclerotic plaques. The definition of the atheroma plaque secretome resides in that proteins secreted by arteries can be very good candidates of novel biomarkers. Finally we describe proteins that have been differentially expressed (versus controls) by individual cells which constitute atheroma plaques (endothelial cells, vascular smooth muscle cells, macrophages and foam cells) as well as by circulating cells (monocytes, platelets) or novel biomarkers present in plasma. Libertas Academica 2008-03-12 /pmc/articles/PMC2688368/ /pubmed/19578499 Text en © 2008 by the authors http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Original Research
Vivanco, F.
Padial, L.R.
Darde, V.M.
de la Cuesta, F.
Alvarez-Llamas, G.
Diaz-Prieto, Natacha
Barderas, M.G.
Proteomic Biomarkers of Atherosclerosis
title Proteomic Biomarkers of Atherosclerosis
title_full Proteomic Biomarkers of Atherosclerosis
title_fullStr Proteomic Biomarkers of Atherosclerosis
title_full_unstemmed Proteomic Biomarkers of Atherosclerosis
title_short Proteomic Biomarkers of Atherosclerosis
title_sort proteomic biomarkers of atherosclerosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688368/
https://www.ncbi.nlm.nih.gov/pubmed/19578499
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