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Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics

BACKGROUND: Pregnane X receptor (PXR) agonists inhibit liver fibrosis. However, the rodent PXR activator pregnenolone 16α carbonitrile (PCN) blocks, in vitro, hepatic stellate cell-to-myofibroblast trans-differentiation and proliferation in cells from mice with a disrupted PXR gene, suggesting there...

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Detalles Bibliográficos
Autores principales:	Marek, Carylyn J, Wallace, Karen, Durward, Elaine, Koruth, Matthew, Leel, Val, Leiper, Lucy J, Wright, Matthew C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688476/ https://www.ncbi.nlm.nih.gov/pubmed/19432992 http://dx.doi.org/10.1186/1476-5926-8-1

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