Cargando…

Chromatin conformation signatures of cellular differentiation

One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation...

Descripción completa

Detalles Bibliográficos
Autores principales: Fraser, James, Rousseau, Mathieu, Shenker, Solomon, Ferraiuolo, Maria A, Hayashizaki, Yoshihide, Blanchette, Mathieu, Dostie, Josée
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688928/
https://www.ncbi.nlm.nih.gov/pubmed/19374771
http://dx.doi.org/10.1186/gb-2009-10-4-r37
_version_ 1782167742278795264
author Fraser, James
Rousseau, Mathieu
Shenker, Solomon
Ferraiuolo, Maria A
Hayashizaki, Yoshihide
Blanchette, Mathieu
Dostie, Josée
author_facet Fraser, James
Rousseau, Mathieu
Shenker, Solomon
Ferraiuolo, Maria A
Hayashizaki, Yoshihide
Blanchette, Mathieu
Dostie, Josée
author_sort Fraser, James
collection PubMed
description One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation signatures with 5C technology . We identified dynamic HoxA cluster chromatin conformation signatures associated with cellular differentiation. Genome-wide chromatin conformation signature identification might uniquely identify disease-associated states and represent an entirely novel class of human disease biomarkers.
format Text
id pubmed-2688928
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-26889282009-06-02 Chromatin conformation signatures of cellular differentiation Fraser, James Rousseau, Mathieu Shenker, Solomon Ferraiuolo, Maria A Hayashizaki, Yoshihide Blanchette, Mathieu Dostie, Josée Genome Biol Software One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the regulation of gene expression. Here, we developed a suite of computer programs to identify chromatin conformation signatures with 5C technology . We identified dynamic HoxA cluster chromatin conformation signatures associated with cellular differentiation. Genome-wide chromatin conformation signature identification might uniquely identify disease-associated states and represent an entirely novel class of human disease biomarkers. BioMed Central 2009 2009-04-19 /pmc/articles/PMC2688928/ /pubmed/19374771 http://dx.doi.org/10.1186/gb-2009-10-4-r37 Text en Copyright © 2009 Fraser et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software
Fraser, James
Rousseau, Mathieu
Shenker, Solomon
Ferraiuolo, Maria A
Hayashizaki, Yoshihide
Blanchette, Mathieu
Dostie, Josée
Chromatin conformation signatures of cellular differentiation
title Chromatin conformation signatures of cellular differentiation
title_full Chromatin conformation signatures of cellular differentiation
title_fullStr Chromatin conformation signatures of cellular differentiation
title_full_unstemmed Chromatin conformation signatures of cellular differentiation
title_short Chromatin conformation signatures of cellular differentiation
title_sort chromatin conformation signatures of cellular differentiation
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688928/
https://www.ncbi.nlm.nih.gov/pubmed/19374771
http://dx.doi.org/10.1186/gb-2009-10-4-r37
work_keys_str_mv AT fraserjames chromatinconformationsignaturesofcellulardifferentiation
AT rousseaumathieu chromatinconformationsignaturesofcellulardifferentiation
AT shenkersolomon chromatinconformationsignaturesofcellulardifferentiation
AT ferraiuolomariaa chromatinconformationsignaturesofcellulardifferentiation
AT hayashizakiyoshihide chromatinconformationsignaturesofcellulardifferentiation
AT blanchettemathieu chromatinconformationsignaturesofcellulardifferentiation
AT dostiejosee chromatinconformationsignaturesofcellulardifferentiation