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Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth...

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Detalles Bibliográficos
Autores principales: Birge, Raymond B, Kalodimos, Charalampos, Inagaki, Fuyuhiko, Tanaka, Shinya
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689226/
https://www.ncbi.nlm.nih.gov/pubmed/19426560
http://dx.doi.org/10.1186/1478-811X-7-13
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author Birge, Raymond B
Kalodimos, Charalampos
Inagaki, Fuyuhiko
Tanaka, Shinya
author_facet Birge, Raymond B
Kalodimos, Charalampos
Inagaki, Fuyuhiko
Tanaka, Shinya
author_sort Birge, Raymond B
collection PubMed
description The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.
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spelling pubmed-26892262009-06-02 Crk and CrkL adaptor proteins: networks for physiological and pathological signaling Birge, Raymond B Kalodimos, Charalampos Inagaki, Fuyuhiko Tanaka, Shinya Cell Commun Signal Review The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses. BioMed Central 2009-05-10 /pmc/articles/PMC2689226/ /pubmed/19426560 http://dx.doi.org/10.1186/1478-811X-7-13 Text en Copyright © 2009 Birge et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Birge, Raymond B
Kalodimos, Charalampos
Inagaki, Fuyuhiko
Tanaka, Shinya
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title_full Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title_fullStr Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title_full_unstemmed Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title_short Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
title_sort crk and crkl adaptor proteins: networks for physiological and pathological signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689226/
https://www.ncbi.nlm.nih.gov/pubmed/19426560
http://dx.doi.org/10.1186/1478-811X-7-13
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