A note on QTL detecting for censored traits

Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecti...

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Detalles Bibliográficos
Autor principal: Fang, Yixin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689307/
https://www.ncbi.nlm.nih.gov/pubmed/16492376
http://dx.doi.org/10.1186/1297-9686-38-2-221
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author Fang, Yixin
author_facet Fang, Yixin
author_sort Fang, Yixin
collection PubMed
description Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".
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spelling pubmed-26893072009-06-02 A note on QTL detecting for censored traits Fang, Yixin Genet Sel Evol Methodology Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance". BioMed Central 2006-02-24 /pmc/articles/PMC2689307/ /pubmed/16492376 http://dx.doi.org/10.1186/1297-9686-38-2-221 Text en Copyright © 2006 INRA, EDP Sciences
spellingShingle Methodology
Fang, Yixin
A note on QTL detecting for censored traits
title A note on QTL detecting for censored traits
title_full A note on QTL detecting for censored traits
title_fullStr A note on QTL detecting for censored traits
title_full_unstemmed A note on QTL detecting for censored traits
title_short A note on QTL detecting for censored traits
title_sort note on qtl detecting for censored traits
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689307/
https://www.ncbi.nlm.nih.gov/pubmed/16492376
http://dx.doi.org/10.1186/1297-9686-38-2-221
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